| Characterization of and host response to tyramine substituted-hyaluronan enriched fascia extracellular matrix. | |
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MedLine Citation:
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PMID: 21553156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Naturally-occurring biomaterial scaffolds derived from extracellular matrix (ECM) have been previously investigated for soft tissue repair. We propose to enrich fascia ECM with high molecular weight tyramine substituted-hyaluronan (TS-HA) to modulate inflammation associated with implantation and enhance fibroblast infiltration. As critical determinants of constructive remodeling, the host inflammatory response and macrophage polarization to TS-HA enriched fascia were characterized in a rat abdominal wall model. TS-HA treated fascia with cross-linking had a similar lymphocyte (P = 0.11) and plasma cell (P = 0.13) densities, greater macrophage (P = 0.001) and giant cell (P < 0.0001) densities, and a lower density of fibroblast-like cells (P < 0.0001) than water treated controls. Treated fascia, with or without cross-linking, exhibited a predominantly M2 pro-remodeling macrophage profile similar to water controls (P = 0.82), which is suggestive of constructive tissue remodeling. Our findings demonstrated that HA augmentation can alter the host response to an ECM, but the appropriate concentration and molecular weight needed to minimize chronic inflammation within the scaffold remains to be determined. |
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Authors:
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Likang Chin; Anthony Calabro; E Rene Rodriguez; Carmela D Tan; Esteban Walker; Kathleen A Derwin |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-05-07 |
Journal Detail:
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Title: Journal of materials science. Materials in medicine Volume: 22 ISSN: 1573-4838 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-15 Completed Date: 2011-11-22 Revised Date: 2012-05-01 |
Medline Journal Info:
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Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
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Languages: eng Pagination: 1465-77 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, ND20, Cleveland, OH 44195, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Wall
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physiology Adolescent Adult Animals Biocompatible Materials / chemistry, pharmacology* Extracellular Matrix / chemistry, drug effects Fascia / chemistry, cytology*, drug effects Humans Hyaluronic Acid / chemistry*, pharmacology Male Middle Aged Rats Rats, Inbred Lew Sympathomimetics / chemistry, pharmacology Tissue Scaffolds / chemistry* Tyramine / chemistry, pharmacology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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F31AR057305/AR/NIAMS NIH HHS; R01 AR056633/AR/NIAMS NIH HHS; R01 AR056633-01/AR/NIAMS NIH HHS; R01AR056633/AR/NIAMS NIH HHS; T32AR50959/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Sympathomimetics; 51-67-2/Tyramine; 9004-61-9/Hyaluronic Acid |
| Comments/Corrections | |
Erratum In:
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J Mater Sci Mater Med. 2011 Jul;22(7):1785 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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