Document Detail

Characterization of hind paw licking and lifting to noxious radiant heat in the rat with and without chronic inflammation.
MedLine Citation:
PMID:  16574243     Owner:  NLM     Status:  MEDLINE    
The paw withdrawal latency to thermal radiant heat stimuli is a widely used nociceptive measure to study hyperalgesic mechanisms. In the present study, in addition to the paw withdrawal latency, two behavioral components of pain behaviors, paw licking and paw lifting have been characterized and quantified. The thermal stimuli were successively applied to the plantar surface of the rat hind paws and recorded the behavioral responses to each of the stimuli. Noxious radiant heat significantly increased the frequency of paw lifting behavior in naïve rats. On the other hand, the thermal stimuli significantly evoked the occurrence of paw licking behavior in inflamed paws and it was maintained at all time points of measurements. The paw withdrawal latency decreased in inflamed rats in comparison with control rats. These data informs that noxious radiant heat specifically evokes the frequency of paw lifting behavior in normal physiological condition, and paw licking behavior in a pathological inflammatory condition. These findings suggest that in addition to the measurement of PWL, scoring of paw licking and lifting behaviors will improve the sensitivity of this pain test.
Bopaiah Pooviah Cheppudira
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Publication Detail:
Type:  Journal Article     Date:  2006-03-29
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  155     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-13     Completed Date:  2006-09-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  122-5     Citation Subset:  IM    
Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
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MeSH Terms
Behavior, Animal / physiology*
Chronic Disease
Disease Models, Animal
Freund's Adjuvant / adverse effects
Grooming / physiology
Hot Temperature / adverse effects
Hyperalgesia / diagnosis,  physiopathology*
Inflammation / diagnosis,  physiopathology*
Inflammation Mediators / adverse effects
Movement / physiology
Neurophysiology / methods*
Pain Measurement / methods*
Rats, Sprague-Dawley
Reaction Time / physiology*
Reflex / physiology
Reg. No./Substance:
0/Inflammation Mediators; 9007-81-2/Freund's Adjuvant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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