Document Detail

Characterization of hepatic glucose metabolism disorder with the progress of diabetes in male Spontaneously Diabetic Torii rats.
MedLine Citation:
PMID:  19057144     Owner:  NLM     Status:  MEDLINE    
The Spontaneously Diabetic Torii (SDT) rat has recently been established as a new model of non-obese type 2 diabetes. In this study, we examined changes in hepatic glucose metabolism in prediabetic and diabetic SDT rats compared with age-matched control rats. The prediabetic state was confirmed at 16 weeks of age, and the diabetic state was confirmed at 24 and 32 weeks of age. Decreases in glucokinase mRNA levels and activity were observed in the prediabetic state. In this state, glycogen synthase activity and glycogen content were also decreased in the SDT rat. In addition to the above changes, glycogen phosphorylase mRNA and activity were decreased and gluconeogenetic enzyme mRNA levels were significantly increased in the diabetic state. These results indicate there is a great potential that abnormalities in hepatic glucose metabolism play a role in the progression to onset of diabetes. We suggest that the SDT rat is a valuable diabetic model for investigations into mechanisms or causes of progression to diabetes.
Hisayo Morinaga; Hiromi Yamamoto; Kaoru Sakata; Sumiaki Fukuda; Makoto Ito; Tomohiko Sasase; Katsuhiro Miyajima; Nobuhisa Ueda; Takeshi Ohta; Mutsuyoshi Matsushita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  70     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-12-05     Completed Date:  2008-12-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1239-45     Citation Subset:  IM    
Japan Tobacco Inc., Central Pharmaceutical Research Institute, Osaka, Japan.
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MeSH Terms
Cholesterol / blood
DNA Primers
Diabetes Mellitus, Type 1 / enzymology,  genetics*
Disease Progression
Glucokinase / genetics,  metabolism
Gluconeogenesis / genetics
Glucose Intolerance / metabolism*
Hypoglycemic Agents / therapeutic use
Insulin / therapeutic use
Liver / enzymology,  metabolism*
Prediabetic State / metabolism
RNA, Messenger / genetics
Rats, Inbred Strains
Triglycerides / blood
Reg. No./Substance:
0/DNA Primers; 0/Hypoglycemic Agents; 0/RNA, Messenger; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol; EC

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