| Characterization of hepatic glucose metabolism disorder with the progress of diabetes in male Spontaneously Diabetic Torii rats. | |
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MedLine Citation:
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PMID: 19057144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Spontaneously Diabetic Torii (SDT) rat has recently been established as a new model of non-obese type 2 diabetes. In this study, we examined changes in hepatic glucose metabolism in prediabetic and diabetic SDT rats compared with age-matched control rats. The prediabetic state was confirmed at 16 weeks of age, and the diabetic state was confirmed at 24 and 32 weeks of age. Decreases in glucokinase mRNA levels and activity were observed in the prediabetic state. In this state, glycogen synthase activity and glycogen content were also decreased in the SDT rat. In addition to the above changes, glycogen phosphorylase mRNA and activity were decreased and gluconeogenetic enzyme mRNA levels were significantly increased in the diabetic state. These results indicate there is a great potential that abnormalities in hepatic glucose metabolism play a role in the progression to onset of diabetes. We suggest that the SDT rat is a valuable diabetic model for investigations into mechanisms or causes of progression to diabetes. |
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Authors:
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Hisayo Morinaga; Hiromi Yamamoto; Kaoru Sakata; Sumiaki Fukuda; Makoto Ito; Tomohiko Sasase; Katsuhiro Miyajima; Nobuhisa Ueda; Takeshi Ohta; Mutsuyoshi Matsushita |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 70 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-12-05 Completed Date: 2008-12-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 1239-45 Citation Subset: IM |
Affiliation:
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Japan Tobacco Inc., Central Pharmaceutical Research Institute, Osaka, Japan. hisayo.morinaga@ims.jti.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Cholesterol / blood DNA Primers Diabetes Mellitus, Type 1 / enzymology, genetics* Disease Progression Glucokinase / genetics, metabolism Gluconeogenesis / genetics Glucose Intolerance / metabolism* Hypoglycemic Agents / therapeutic use Insulin / therapeutic use Liver / enzymology, metabolism* Male Prediabetic State / metabolism RNA, Messenger / genetics Rats Rats, Inbred Strains Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Hypoglycemic Agents; 0/RNA, Messenger; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol; EC 2.7.1.2/Glucokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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