| Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH. | |
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MedLine Citation:
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PMID: 23055155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONCLUSIONS: The increased abundance of alcohol-producing bacteria in NASH microbiomes, elevated blood-ethanol concentration in NASH patients, and the well-established role of alcohol metabolism in oxidative stress and, consequently, liver inflammation suggest a role for alcohol-producing microbiota in the pathogenesis of NASH. We postulate that the distinct composition of the gut microbiome among NASH, obese, and healthy controls could offer a target for intervention or a marker for disease. |
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Authors:
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Lixin Zhu; Susan S Baker; Chelsea Gill; Wensheng Liu; Razan Alkhouri; Robert D Baker; Steven R Gill |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2013-01-08 |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 57 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-02-06 Completed Date: 2013-04-04 Revised Date: 2013-05-21 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
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Languages: eng Pagination: 601-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 American Association for the Study of Liver Diseases. |
Affiliation:
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Digestive Diseases and Nutrition Center, Department of Pediatrics, State University of New York at Buffalo, Buffalo, NY 14214, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Bacteroides / classification, isolation & purification Child Ethanol / metabolism* Fatty Liver / microbiology* Female Gastrointestinal Tract / microbiology* Humans Male Metagenome* Obesity / microbiology* Prevotella / isolation & purification Proteobacteria / classification, isolation & purification RNA, Ribosomal, 16S / genetics |
| Chemical | |
Reg. No./Substance:
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0/RNA, Ribosomal, 16S; 64-17-5/Ethanol |
| Comments/Corrections | |
Comment In:
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Nat Rev Gastroenterol Hepatol. 2012 Dec;9(12):687
[PMID:
23147655
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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