Document Detail


Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH.
MedLine Citation:
PMID:  23055155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSIONS: The increased abundance of alcohol-producing bacteria in NASH microbiomes, elevated blood-ethanol concentration in NASH patients, and the well-established role of alcohol metabolism in oxidative stress and, consequently, liver inflammation suggest a role for alcohol-producing microbiota in the pathogenesis of NASH. We postulate that the distinct composition of the gut microbiome among NASH, obese, and healthy controls could offer a target for intervention or a marker for disease.
Authors:
Lixin Zhu; Susan S Baker; Chelsea Gill; Wensheng Liu; Razan Alkhouri; Robert D Baker; Steven R Gill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-08
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-06     Completed Date:  2013-04-04     Revised Date:  2014-06-17    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  601-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Bacteroides / classification,  isolation & purification
Child
Ethanol / metabolism*
Fatty Liver / microbiology*
Female
Gastrointestinal Tract / microbiology*
Humans
Male
Metagenome*
Obesity / microbiology*
Prevotella / isolation & purification
Proteobacteria / classification,  isolation & purification
RNA, Ribosomal, 16S / genetics
Chemical
Reg. No./Substance:
0/RNA, Ribosomal, 16S; 3K9958V90M/Ethanol
Comments/Corrections
Comment In:
Nat Rev Gastroenterol Hepatol. 2012 Dec;9(12):687   [PMID:  23147655 ]
Z Gastroenterol. 2014 May;52(5):453-5   [PMID:  24824912 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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