Document Detail


Characterization of the genomic structure of the mouse APLP1 gene.
MedLine Citation:
PMID:  8786110     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amyloid beta protein (beta A4), the major component of the core of amyloid plaques in Alzheimer disease, is derived from the transmembrane amyloid precursor proteins (APPs). Our recent studies showed that a murine member of the evolutionarily conserved APP family, amyloid precursor-like protein 1 (APLP1), is specifically localized to the cerebral cortex postsynaptic density and may thus participate in brain synaptic function. To investigate regulatory mechanisms of APLP1 synthesis at the genomic level, we isolated and characterized genomic clones containing the mouse APLP1 gene. Sequence analysis revealed a genomic structure consisting of 17 exons and a promoter region that is devoid of apparent TATA and CCAAT boxes. The 5' region contains putative binding sites for AP-1, heat-shock protein, and Sp1, suggesting that multiple elements are potentially involved in regulating transcription of the APLP1 gene.
Authors:
S Zhong; K Wu; I B Black; D G Schaar
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  32     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-09-20     Completed Date:  1996-09-20     Revised Date:  2011-08-04    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  159-62     Citation Subset:  IM    
Affiliation:
Department of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/U33503
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / etiology,  genetics
Amyloid beta-Protein Precursor / analogs & derivatives*,  genetics
Animals
Base Sequence
Consensus Sequence
DNA, Complementary / genetics
Evolution, Molecular
Exons
Genes, Regulator
Genome*
Humans
Mice
Molecular Sequence Data
Grant Support
ID/Acronym/Agency:
HD23315/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/APLP1 protein, human; 0/Amyloid beta-Protein Precursor; 0/Aplp1 protein, mouse; 0/DNA, Complementary

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