Document Detail

Characterization of four short tandem repeat loci (THO1, VWA31/A, CD4, and TP53) in northern Portugal.
MedLine Citation:
PMID:  9037893     Owner:  NLM     Status:  MEDLINE    
Allele and genotype frequencies for two tetrameric and two pentameric short tandem repeat (STR) loci (THO1, VWA31/A, CD4, and TP53) were determined in a population sample from northern Portugal. Genotyping of PCR amplification products was done using polyacrylamide gel electrophoresis followed by silver staining; heteroduplex analysis was performed to distinguish THO1 genotypes involving allele 10 and the nonconsensus allele 9.3. For all loci allele frequencies fitted the distribution patterns generally observed in European populations. The observed genotype distributions do not deviate significantly from Hardy-Weinberg expectations, although for VWA31/A a significant excess of heterozygotes involving allele 17 was found. Mother-child pair analyses confirmed the regular Mendelian pattern of inheritance. Because the information content of these systems is high and because their genotyping is technically reliable and simple, CD4, THO1, VWA31/A, and TP53 are appropriate genetic systems for anthropological genetics.
L Gusmão; M J Prata; A Amorim; F Silva; I Bessa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human biology     Volume:  69     ISSN:  0018-7143     ISO Abbreviation:  Hum. Biol.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-05-01     Completed Date:  1997-05-01     Revised Date:  2011-04-18    
Medline Journal Info:
Nlm Unique ID:  0116717     Medline TA:  Hum Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-40     Citation Subset:  IM    
Instituto de Antropologia, Faculdade de Ciências, Universidade do Porto, Praça Gomes Teixeira, Portugal.
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MeSH Terms
Antigens, CD / genetics*
Genes, p53 / genetics*
Polymorphism, Genetic*
Repetitive Sequences, Nucleic Acid*
Tyrosine 3-Monooxygenase / genetics*
von Willebrand Factor / genetics*
Reg. No./Substance:
0/Antigens, CD; 0/von Willebrand Factor; EC 3-Monooxygenase

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