Document Detail

Characterization of the first molluscicidal lipopolysaccharide from Moraxella osloensis.
MedLine Citation:
PMID:  12788774     Owner:  NLM     Status:  MEDLINE    
Moraxella osloensis is a bacterium that is mutualistically associated with Phasmarhabditis hermaphrodita, a nematode that has potential for the biocontrol of mollusk pests, especially the slug Deroceras reticulatum. We discovered that purified M. osloensis lipopolysaccharide (LPS) possesses a lethal toxicity to D. reticulatum when administered by injection but no contact or oral toxicity to this slug. The toxicity of the LPS resides in the lipid A moiety. M. osloensis LPS was semiquantitated at 6 x 10(7) endotoxin units per mg. The LPS is a rough-type LPS with an estimated molecular weight of 5,300. Coinjection of galactosamine with the LPS increased the LPS's toxicity to the slug two- to four-fold. The galactosamine-induced sensitization of the slug to the LPS was reversed completely by uridine.
Li Tan; Parwinder S Grewal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  69     ISSN:  0099-2240     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-05     Completed Date:  2003-10-01     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3646-9     Citation Subset:  IM    
Department of Entomology, Ohio Agricultural Research and Development Center, Ohio State University, Wooster, Ohio 44691, USA.
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MeSH Terms
Endotoxins / administration & dosage,  chemistry,  metabolism
Galactosamine / pharmacology
Lipopolysaccharides / administration & dosage*,  chemistry*,  metabolism
Mollusca / drug effects*
Moraxella / metabolism*
Pest Control, Biological*
Rhabditida / microbiology
Reg. No./Substance:
0/Endotoxins; 0/Lipopolysaccharides; 7535-00-4/Galactosamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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