Document Detail


Characterization of the erythropoiesis in myelodysplasia by means of ferrokinetic studies, in vitro erythroid colony formation and soluble transferrin receptor.
MedLine Citation:
PMID:  9529128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In refractory anemia (RA) and refractory anemia with ringed sideroblasts (RARS) a discrepancy is observed between the decreased in vitro erythroid colony formation and the normal or increased number of normoblasts in the bone marrow. To study the in vivo and in vitro erythropoiesis in more detail erythron transferrin uptake (ETU), soluble transferrin receptor (sTfR) and erythroid in vitro colony formation were performed in 24 patients with RA and five patients with RARS. These results were correlated with bone marrow morphology and transfusion dependency. Increased (mean, 124.9; range, 74-225 micromol/l blood/day) and normal (mean, 60.6; range, 50-71) ETU values were observed in 51% and 28% of the cases, whereas 21% of the cases demonstrated a diminished ETU value (mean, 35.8; range, 28-46), which correlated significantly with sTfR in cases with RA (P < 0.05, r = 0.64). A significant difference in ETU values was observed between RA (mean, 77.6; range, 28-189) and RARS (mean, 144.0; range, 59-225, P < 0.05). Most of the cases (73%) with increased ETU values showed an augmented percentage of erythroblasts in the bone marrow, which was inversely related with the serum Epo levels (P < 0.05, r = 0.51). However no correlation was found between the ETU values and the in vitro erythroid colony formation. Transfusion dependency was associated with normal to increased ETU levels (P < 0.05) and cytogenetic abnormalities (P < 0.05). These observations demonstrate that different patterns of defects can be observed in the erythropoiesis of RA and RARS patients whereby normal to increased ETU levels and the presence of cytogenetic abnormalities differentiate between cases of RA with ineffective erythropoiesis associated with regular transfusions and cases who are relatively transfusion independent.
Authors:
S J Brada; J T de Wolf; D Hendriks; H Louwes; E van den Berg; E Vellenga
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia     Volume:  12     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-04-16     Completed Date:  1998-04-16     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  340-5     Citation Subset:  IM    
Affiliation:
Department of Hematology, University Hospital, Groningen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anemia, Refractory / blood,  pathology,  physiopathology*,  therapy
Anemia, Refractory, with Excess of Blasts / blood,  pathology,  physiopathology,  therapy
Blood Transfusion
Bone Marrow Cells / pathology*
Cells, Cultured
Colony-Forming Units Assay
Erythropoiesis*
Erythropoietin / blood
Hematocrit
Hematopoietic Stem Cells / pathology*,  physiology
Humans
Leukocyte Count
Middle Aged
Platelet Count
Receptors, Transferrin / biosynthesis*,  blood
Reticulocyte Count
Transferrin / metabolism*
Chemical
Reg. No./Substance:
0/Receptors, Transferrin; 0/Transferrin; 11096-26-7/Erythropoietin

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