Document Detail

Characterization of endometrial T lymphocyte subpopulations in spontaneous early pregnancy loss.
MedLine Citation:
PMID:  9512226     Owner:  NLM     Status:  MEDLINE    
T lymphocyte subpopulations were compared in normal first trimester human decidua and in decidua associated with spontaneous abortion. Cryostat sections were labelled using a panel of monoclonal antibodies specific for CD3, CD8, CD4 and for the alphabeta and gammadelta heterodimers of the T cell receptor using an avidin-biotin complex peroxidase method. All the endometrial T cell subsets which have been demonstrated in normal early pregnancy were detected in similar numbers and proportions in spontaneous abortion. The findings suggest that adverse pregnancy outcome is not influenced by altered proportions of T cell subpopulations; nevertheless, the possibility remains that these cells may have an altered antigenic phenotype in spontaneous abortion which could contribute to pregnancy success or failure.
N Vassiliadou; J N Bulmer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  13     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-04-29     Completed Date:  1998-04-29     Revised Date:  2010-08-25    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  44-7     Citation Subset:  IM; X    
Department of Pathology, University of Newcastle, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
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MeSH Terms
Abortion, Spontaneous / immunology*
CD4-Positive T-Lymphocytes / immunology
CD8-Positive T-Lymphocytes / immunology
Case-Control Studies
Decidua / immunology*
Endometrium / immunology*
Receptors, Antigen, T-Cell / blood
T-Lymphocyte Subsets / immunology*
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Receptors, Antigen, T-Cell

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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