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Characterization of the effects of the vasopressin V2 receptor on sweating, fluid balance and performance during exercise.
MedLine Citation:
PMID:  24944242     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A regulatory effect of arginine vasopressin (AVP) on sweat water conservation has been hypothesized but not definitively evaluated. AVP-mediated insertion of sweat and salivary gland aquaporin-5 (AQP5) water channels through activation of the vasopressin type 2 receptor (V2R) remains an attractive, yet unexplored, mechanism that could result in a more concentrated sweat with resultant decreased water loss. Ten runners participated in a double-blind randomized control treadmill trial under three separate pharmacologic conditions: placebo; V2R agonist (0.2mg desmopressin); or V2R antagonist (30mg tolvaptan). After a familiarization trial, runners ran for 60 minutes at 60% of peak speed followed by a performance trial to volitional exhaustion. Outcome variables were collected at three exercise time points: baseline, after the steady-state run, and after the performance run. Bodyweight losses were <2% across all three trials. Significant pharmacological condition effects were noted for urine osmolality [F=84.98;p<0.0001] and urine sodium concentration ([Na(+)]) [F=38.9;p<0.0001], which verified both pharmacological activation and inhibition of the V2R at the kidney collecting duct. Plasma osmolality and [Na(+)] demonstrated significant exercise (F=26.0 and F=11.1;p<0.0001) and condition (F=5.1 and F=3.8;p<0.05) effects. No significant exercise or condition effects were noted for either sweat or salivary [Na(+)]. Significant exercise effects were noted for plasma [AVP] (F=22.3;p<0.0001), peak core temperature (F=103.3;p<0.0001), percent bodyweight change (F=6.3;p=0.02), plasma volume change (F=21.8;p<0.0001), and thirst rating (F=78.2;p<0.0001). Performance time was not altered between conditions (P=0.80). In summary, AVP acting at V2R does not appear to regulate water losses from body fluids other than renal excretion during exercise.
Authors:
Tamara Dawn Hew-Butler; Jed Hummel; Brian Rider; Joseph G Verbalis
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-18
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology.
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