| Characterization of the effects of butyric acid on cell proliferation, cell cycle distribution and apoptosis. | |
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MedLine Citation:
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PMID: 16706789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined concentration-dependent changes in cell cycle distribution and cell cycle-related proteins induced by butyric acid. Butyric acid enhanced or suppressed the proliferation of Jurkat human T lymphocytes depending on concentration. A low concentration of butyric acid induced a massive increase in the number of cells in S and G2/M phases, whereas a high concentration significantly increased the accumulation of cells in G2/M phase, suppressed the accumulation of cells in G0/G1 and S phases, and induced apoptosis that cell cycle-related protein expression in Jurkat cells treated with high levels of butyric acid caused a marked decrease in cyclin A, cyclin E, cyclin-dependent kinase 2 (CDK2), CDK4 and CDK6 protein levels in G0/G1 and S phases, with apoptosis induction, and a decrease in cyclin B, Cdc25c and p27KIP1 protein levels, as well as an increase in p21CIP1/WAF1 protein level, in the G2/M phase. Taken together, our results indicate that butyric acid has bimodal effects on cell proliferation and survival. The inhibition of cell growth followed by the increase in apoptosis induced by high levels of butyric acid were related to an increase in cell death in G0/G1 and S phases, as well as G2/M arrest of cells. Finally, these results were further substantiated by the expression profile of butyric acid-treated Jurkat cells obtained by means of cDNA array. |
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Authors:
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Tomoko Kurita-Ochiai; Tomomi Hashizume; Hideo Yonezawa; Kuniyasu Ochiai; Masafumi Yamamoto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEMS immunology and medical microbiology Volume: 47 ISSN: 0928-8244 ISO Abbreviation: FEMS Immunol. Med. Microbiol. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-18 Completed Date: 2006-08-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9315554 Medline TA: FEMS Immunol Med Microbiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 67-74 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, Chiba, Japan. ochai.tomoko@nihon-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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drug effects* Butyric Acid / pharmacology* Cell Cycle / drug effects* Cell Cycle Proteins / biosynthesis Cell Proliferation / drug effects Dose-Response Relationship, Drug Humans Jurkat Cells Oligonucleotide Array Sequence Analysis T-Lymphocytes / cytology, drug effects*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 107-92-6/Butyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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