Document Detail

Characterization of early pathogenic effects after experimental infection of calves with bovine immunodeficiency-like virus.
MedLine Citation:
PMID:  1309889     Owner:  NLM     Status:  MEDLINE    
The early pathogenic effects of bovine immunodeficiency-like virus (BIV) were studied in calves experimentally inoculated with BIV. All animals inoculated with BIV R29-infected cells seroconverted by 6 weeks postinoculation, and BIV was recoverable from each animal at 2 weeks postinoculation. However, levels of BIV replication in vivo appeared to be low. In situ hybridization studies indicated that during peak periods of viral replication in vivo, less than 0.03% of peripheral blood mononuclear cells were expressing detectable levels of viral RNA. Moreover, the levels of viral RNA in these cells in vivo were less than 1/10 the levels observed in persistently infected cells in vitro. BIV-inoculated calves had significantly higher numbers of circulating lymphocytes, and follicular hyperplasia was observed in lymph nodes, hemal nodes, and spleen. The histopathological changes observed in BIV-infected calves were similar to changes found early after infection with the immunosuppressive lentiviruses, including human immunodeficiency virus type 1.
S Carpenter; L D Miller; S Alexandersen; C A Whetstone; M J VanDerMaaten; B Viuff; Y Wannemuehler; J M Miller; J A Roth
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of virology     Volume:  66     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-02-14     Completed Date:  1992-02-14     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1074-83     Citation Subset:  IM; X    
Department of Microbiology, Immunology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames 50011.
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MeSH Terms
Antibodies, Viral / analysis
Cattle Diseases / microbiology*,  pathology,  physiopathology
Immunodeficiency Virus, Bovine / genetics,  isolation & purification,  pathogenicity*
Lentivirus Infections / pathology,  physiopathology,  veterinary*
Leukocyte Count
Lymph Nodes / pathology
Lymphocytes / physiology
Neutrophils / physiology
Repetitive Sequences, Nucleic Acid
Time Factors
Grant Support
Reg. No./Substance:
0/Antibodies, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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