Document Detail


Characterization of the diversity and temporal stability of bacterial communities in human milk.
MedLine Citation:
PMID:  21695057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent investigations have demonstrated that human milk contains a variety of bacterial genera; however, as of yet very little work has been done to characterize the full diversity of these milk bacterial communities and their relative stability over time. To more thoroughly investigate the human milk microbiome, we utilized microbial identification techniques based on pyrosequencing of the 16S ribosomal RNA gene. Specifically, we characterized the bacterial communities present in milk samples collected from 16 women at three time-points over four weeks. Results indicated that milk bacterial communities were generally complex; several genera represented greater than 5% of the relative community abundance, and the community was often, yet not always, stable over time within an individual. These results support the conclusion that human milk, which is recommended as the optimal nutrition source for almost all healthy infants, contains a collection of bacteria more diverse than previously reported. This finding begs the question as to what role this community plays in colonization of the infant gastrointestinal tract and maintaining mammary health.
Authors:
Katherine M Hunt; James A Foster; Larry J Forney; Ursel M E Schütte; Daniel L Beck; Zaid Abdo; Lawrence K Fox; Janet E Williams; Michelle K McGuire; Mark A McGuire
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-06-17
Journal Detail:
Title:  PloS one     Volume:  6     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-22     Completed Date:  2011-10-21     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e21313     Citation Subset:  IM    
Affiliation:
Department of Animal and Veterinary Science, University of Idaho, Moscow, Idaho, United States of America.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bacteria / classification*
Biodiversity*
Female
Humans
Lactation
Milk, Human / microbiology*
Phylogeny
Time Factors
Young Adult
Grant Support
ID/Acronym/Agency:
P20 RR016454/RR/NCRR NIH HHS; P20 RR15587/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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