Document Detail

Characterization of the disposition of melamine in female sprague-dawley rats using ultra-performance liquid chromatography-tandem mass spectrometry.
MedLine Citation:
PMID:  22004674     Owner:  NLM     Status:  In-Data-Review    
This study characterized the concentration-time profile of melamine in the heart, liver, spleen, lungs, kidneys, bladder, feces, urine, and plasma after melamine (MM) administration. Female Sprague-Dawley rats received a single oral dose of 1.0 g/kg body weight. Samples (n = 4 per time point) were collected at 12, 24, 48, 72, 96, 120, 144, and 168 h. Based on calculations of the area under the concentration-time curves after dosing, ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) was used to detect MM concentration in tissues. Peak concentrations of MM are reached in the livers and lungs at 12 h after dosing and in hearts, spleens, kidneys, bladders, feces, urine, and plasma at 24 h after dosing. More than 90% of the ingested MM is excreted in feces and urine within 24 h. These results provided initial understanding of the tissue disposition of MM. Moreover, this study demonstrates that UPLC-MS-MS can be used to detect MM in biological samples.
Desheng Wu; Jianjun Liu; Qionghui Zhao; Xinyun Xu; Linqing Yang; Haiyan Huang; Jianhui Yuan; Li Zhou; Zhixiong Zhuang
Related Documents :
22720954 - Nationwide evaluation of quality and composition of colostrum on dairy farms in the uni...
22943884 - Life-long accumulation of (137)cs and (40)k in the vertebral column of a cow.
19627514 - Detection of gingival crevicular fluid mmp-8 levels with different laboratory and chair...
22987614 - An efficient method for purification of nonspecific lipid transfer protein-1 from rice ...
21126384 - Morphological confocal microscopy in arthropods and the enhancement of autofluorescence...
15387194 - Solid-phase microextraction-gas chromatography-mass spectrometry for the analysis of se...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of analytical toxicology     Volume:  35     ISSN:  1945-2403     ISO Abbreviation:  J Anal Toxicol     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705085     Medline TA:  J Anal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  551-7     Citation Subset:  IM    
Key Laboratory of Modern Toxicology of Shenzhen, Medical Key Laboratory of Health Toxicology, Laboratory of Modern Toxicology, Shenzhen Centre for Disease Control and Prevention, Shenzhen, 518060, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Determination of levamisole in urine by gas chromatography-mass spectrometry.
Next Document:  Determination of sunitinib and its active metabolite N-desethylsunitinib in sweat of a patient.