| Characterization of the discriminative stimulus effects of gamma-hydroxybutyric acid as a means for unraveling the neurochemical basis of gamma-hydroxybutyric acid actions and its similarities to those of ethanol. | |
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MedLine Citation:
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PMID: 10869865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present paper reviews the drug discrimination studies, both from the literature and from this laboratory, conducted to investigate the pharmacological profile of the discriminative stimulus effects of gamma-hydroxybutyric acid. Collectively, the results of these studies suggest that: (1) the discriminative stimulus effects of gamma-hydroxybutyric acid are composed of different cues, each one being the effect of gamma-hydroxybutyric acid on a specific receptor system; (2) the proportion of each component cue varies as the training dose of gamma-hydroxybutyric acid is increased; (3) the gamma-aminobutyric acid B-mediated cue is a major ingredient of the mixed stimulus of gamma-hydroxybutyric acid, but it is more prominent at high training doses than at low training doses of gamma-hydroxybutyric acid; and (4) positive modulation of the gamma-aminobutyric acid A receptor is a relevant part of the discriminative stimulus effects of low gamma-hydroxybutyric acid doses. Finally, data indicating symmetrical generalization between the discriminative stimulus effects of a specific range of doses of gamma-hydroxybutyric acid and those of ethanol are discussed in regard to their further support of the hypothesis that gamma-hydroxybutyric acid may exert its antialcohol effects through a substitution mechanism. |
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Authors:
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G Colombo; R Agabio; M A Carai; C Lobina; M Pani; R Reali; G L Gessa |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Alcohol (Fayetteville, N.Y.) Volume: 20 ISSN: 0741-8329 ISO Abbreviation: Alcohol Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-08-11 Completed Date: 2000-08-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502311 Medline TA: Alcohol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 237-45 Citation Subset: IM |
Affiliation:
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C. N. R. Center for Neuropharmacology, University of Cagliari, Via Porcell 4, I-09124, Cagliari, Italy. colomb@unica.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Discrimination (Psychology) Ethanol / pharmacology* Humans Hydroxybutyrates / pharmacology* gamma-Aminobutyric Acid / physiology |
| Chemical | |
Reg. No./Substance:
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0/Hydroxybutyrates; 56-12-2/gamma-Aminobutyric Acid; 591-81-1/4-hydroxybutyric acid; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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