Document Detail


Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe.
MedLine Citation:
PMID:  14648564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability to quantify pulmonary diffusing capacity and perfusion using dynamic hyperpolarized (129)Xe NMR spectroscopy is demonstrated. A model of alveolar gas exchange was developed, which, in conjunction with (129)Xe NMR, enables quantification of average alveolar wall thickness, pulmonary perfusion, capillary diffusion length, and mean transit time. The technique was employed to compare a group of naïve rats (n = 10) with a group of rats with acute inflammatory lung injury (n = 10), caused by instillation of lipopolysaccaride (LPS). The measured structural and perfusion-related parameters were in agreement with reported values from studies using non-NMR methods. Significant differences between the groups were found in total diffusion length (control 8.5 +/- 0.5 microm, LPS 9.9 +/- 0.6 microm, P < 0.001), in capillary diffusion length (control 2.9 +/- 0.4 microm, LPS 3.9 +/- 1.0 microm, P < 0.05), and in pulmonary hematocrit (control 0.55 +/- 0.06, LPS 0.43 +/- 0.08, P < 0.01), whereas no differences were observed in alveolar wall thickness, pulmonary perfusion, and mean transit time. These results demonstrate the ability of the method to distinguish two main aspects of lung function, namely, diffusing capacity and pulmonary perfusion.
Authors:
Sven Månsson; Jan Wolber; Bastiaan Driehuys; Per Wollmer; Klaes Golman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  50     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1170-9     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Affiliation:
Department of Experimental Research, Malmö University Hospital, Malmö, Sweden. sven.mansson@rontgen.mas.lu.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Capillary Permeability
Lipopolysaccharides
Magnetic Resonance Spectroscopy*
Male
Pulmonary Alveoli / physiopathology
Pulmonary Circulation*
Pulmonary Diffusing Capacity*
Rats
Rats, Wistar
Respiratory Distress Syndrome, Adult / chemically induced,  diagnosis,  physiopathology*
Xenon Isotopes / diagnostic use*
Chemical
Reg. No./Substance:
0/Lipopolysaccharides; 0/Xenon Isotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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