Document Detail


Characterization of a degenerative cardiomyopathy associated with domoic acid toxicity in California sea lions (Zalophus californianus).
MedLine Citation:
PMID:  19112124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Domoic acid, produced by marine algae, can cause acute and chronic neurologic sequela in California sea lions (Zalophus californianus) from acute toxicity or sublethal exposure. Eight sea lions, representing acute and chronic cases, both sexes, and all age classes, were selected to demonstrate a concurrent degenerative cardiomyopathy. Critical aspects of characterizing the cardiomyopathy by lesion distribution and morphology were the development of a heart dissection and tissue-trimming protocol and the delineation of the cardiac conducting system by histomorphology and immunohistochemistry for neuron-specific protein gene product 9.5. Histopathologic features and progression of the cardiomyopathy are described, varying from acute to chronic active and mild to severe. The cardiomyopathy is distinguished from other heart lesions in pinnipeds. Based on histopathologic features, immunopositive staining for cleaved caspase-3, and comparison with known, similar-appearing cardiomyopathies, the proposed pathogenesis for the degenerative cardiomyopathy is the primary or at least initial direct interaction of domoic acid with receptors that are suspected to exist in the heart. l-Carnitine, measured in the heart and skeletal muscle, and troponin-I, measured in serum collected at the time of death from additional animals (n = 58), were not predictive of the domoic acid-associated cardiomyopathy. This degenerative cardiomyopathy in California sea lions represents another syndrome beyond central neurologic disease associated with exposure to domoic acid and may contribute to morbidity and mortality.
Authors:
T S Zabka; T Goldstein; C Cross; R W Mueller; C Kreuder-Johnson; S Gill; F M D Gulland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Veterinary pathology     Volume:  46     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-29     Completed Date:  2009-03-31     Revised Date:  2009-06-09    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-19     Citation Subset:  IM    
Affiliation:
Marine Mammal Center, GGNRA, Sausalito, CA, USA. tszabka@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomyopathies / chemically induced*,  pathology*,  veterinary*
Caspase 3 / metabolism
Dissection / methods,  veterinary
Female
Immunohistochemistry
Kainic Acid / analogs & derivatives*,  toxicity
Male
Marine Toxins / toxicity*
Myocardium / pathology
Neurotoxins / toxicity*
Sea Lions*
Chemical
Reg. No./Substance:
0/Marine Toxins; 0/Neurotoxins; 14277-97-5/domoic acid; 487-79-6/Kainic Acid; EC 3.4.22.-/Caspase 3
Comments/Corrections
Erratum In:
Vet Pathol. 2009 May;46(3):552

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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