| Characterization of costal cartilage collagen in funnel chest. | |
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MedLine Citation:
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PMID: 1841625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Parallel measurements of pyridinoline content, the ratio of soluble:insoluble collagen, and the percentage of endogenous collagenolysis were made in samples of costal cartilage from forty-five children with funnel chest (FC) and from twenty-two control children. From an analysis of the influence of different factors, such as FC type (isolated or syndromic), a diagnosed syndrome, extent of FC depression (second or third), and age, two biochemical variants of FC-variants a and b, which were not related to the presence or absence of a known concurrent syndrome, were distinguished. These variants differed from each other in all the parameters under study. Variant a occurred about five times less frequently than b, and was characterized by a pyridinoline content of about 50% of that of b, an elevated soluble:insoluble collagen ratio, and an increased percentage of endogenous collagenolysis compared to controls. For variant b, the pyridinoline content fell within normal limits, but the soluble:insoluble collagen ratio, and the percentage of endogenous collagenolysis were below normal. The data suggest that the formation of variant a may be related to defect(s) in collagen crosslinking, whereas the formation of variant b may result from other unknown factor(s) involved in the formation and maturation of costal cartilage. |
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Authors:
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N N Prozorovskaya; E A Kozlov; A V Voronov; V A Verovskii; A A Delvig |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomedical science Volume: 2 ISSN: 0955-9701 ISO Abbreviation: Biomed. Sci. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-12-21 Completed Date: 1992-12-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9010320 Medline TA: Biomed Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 576-80 Citation Subset: IM |
Affiliation:
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Institute of Biological and Medical Chemistry, Russian Academy of Medical Sciences, Moscow. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Amino Acids Cartilage / chemistry* Child Child, Preschool Collagen / chemistry*, metabolism Funnel Chest / metabolism* Humans Solubility |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 63800-01-1/pyridinoline; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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