| Characterization of coronary atherosclerosis by dual-source computed tomography and HU-based color mapping: a pilot study. | |
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MedLine Citation:
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PMID: 18491107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess HU-based color mapping for characterization of coronary plaque, using intravascular ultrasound virtual histology (IVUS-VH) as a standard of reference. Dual-source computed tomography and IVUS-VH were prospectively performed in 13 patients. In five lesions, HU thresholds of the color-coding software were calibrated to IVUS-VH. In a 15-lesion verification cohort, volumes of vessel, lumen and plaque or percentages of lipid, fibrous and calcified components were obtained through use of pre-set HU cut-offs as well as through purely visual adjustment of color maps. Calibrated HU ranges for fatty or fibrous plaque, lumen and calcification were -10-69, 70-158, 159-436 and 437+. Using these cut-offs, HU-based analysis achieved good agreement of plaque volume with IVUS (47.0 vs. 51.0 mm(3)). Visual segmentation led to significant overestimation of atheroma (61.6 vs. 51.0 mm(3); P = 0.04) Correlation coefficients for volumes of vessel, lumen and plaque were 0.92, 0.87 and 0.83 with HU-based analysis or 0.92, 0.85 and 0.71 with visual evaluation. With both methods, correlation of percentage plaque composition was poor or insignificant. HU-based plaque analysis showed good reproducibility with intra-class correlation coefficients being 0.90 for plaque volume and 0.81, 0.94 or 0.98 for percentages of fatty, fibrous or calcified components. With use of optimized HU thresholds, color mapping allows for accurate and reproducible quantification of coronary plaque. |
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Authors:
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H Brodoefel; A Reimann; M Heuschmid; I Tsiflikas; A F Kopp; S Schroeder; C D Claussen; M E Clouse; C Burgstahler |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-05-20 |
Journal Detail:
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Title: European radiology Volume: 18 ISSN: 1432-1084 ISO Abbreviation: Eur Radiol Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-13 Completed Date: 2009-04-06 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 2466-74 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, Eberhard-Karls-University, Tübingen, Germany. hbrodofe@bidmc.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Angiography / methods* Coronary Artery Disease / radiography*, ultrasonography* Echocardiography, Doppler, Color / methods* Female Humans Male Pilot Projects Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed / methods* |
| Grant Support | |
ID/Acronym/Agency:
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P50 HL083813-05/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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