| Characterization of conotruncal malformations following ablation of "cardiac" neural crest. | |
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MedLine Citation:
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PMID: 4073565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neural crest cells from the cranial region of the neural fold populate the outflow tract of the developing chick heart. Removal of this region of premigratory neural crest has been shown previously to result in a high percentage of conotruncal malformations. The present study was undertaken to define more precisely the regions of premigratory neural crest which are needed for normal conotruncal development. Various regions and lengths of premigratory cranial neural crest were ablated using microcautery. Three defects in conotruncal development were significantly correlated with the neural crest ablation. These were high ventricular septal defect, single outflow vessel originating from the right ventricle, and single outflow vessel overriding the ventricular septum. |
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Authors:
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M L Kirby; K L Turnage; B M Hays |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Anatomical record Volume: 213 ISSN: 0003-276X ISO Abbreviation: Anat. Rec. Publication Date: 1985 Sep |
Date Detail:
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Created Date: 1986-01-03 Completed Date: 1986-01-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370540 Medline TA: Anat Rec Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 87-93 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Vessels / abnormalities Cautery / methods Chick Embryo Coronary Circulation Heart Defects, Congenital / embryology*, etiology Heart Septal Defects, Ventricular / embryology, epidemiology, etiology Neural Crest / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL 32546/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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