Document Detail

Characterization and clinical outcomes of drug-eluting in-stent restenosis.
MedLine Citation:
PMID:  20929078     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The best therapeutic alternative for patients suffering from in-stent restenosis after drug-eluting stent implantation remains to be elucidated. OBJECTIVE: To characterize the pattern, treatment and outcomes of DES-related in-stent restenosis in patients treated at our institution. METHODS: We determined the incidence and major adverse clinical events in 71 consecutive patients with DES failure among 2473 patients who were treated with 2548 drug-eluting stents between 2004 and 2007. We analyzed the clinical data, procedural parameters and clinical outcomes. RESULTS: The type and number of stents implanted were as follows: Cypher (n = 1808), Endeavor (421) and Taxus (319); of these, 53 (2.9%), 10 (2.4%), and 8 (2.5%) patients respectively presented with restenosis. The mean time to restenosis was 11.3 +/- 9.9 months. Patients' mean age was 65 +/- 11 years; 75% were male, and 68% had diabetes mellitus. Unstable angina was the clinical presentation in 52 (73%). At 6 months, 3 patients had developed myocardial infarction (4.2%), repeat restenosis at follow-up was diagnosed in 8 patients (11.3%), the overall major adverse clinical events rate was 18.3% (13 patients), and 2 patients died (2.8%). CONCLUSIONS: Drug-eluting stent-related restenosis is relatively infrequent but remains a clinical challenge. It occurs more frequently in complex lesion subsets, but the overall intermediate-term prognosis is tolerable.
Hana Vaknin-Assa; Abid Assali; Eli Lev; Itzik Ben-Dor; David Brosh; Igal Teplitsky; Ran Kornowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Israel Medical Association journal : IMAJ     Volume:  12     ISSN:  1565-1088     ISO Abbreviation:  Isr. Med. Assoc. J.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-10-08     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100930740     Medline TA:  Isr Med Assoc J     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  273-6     Citation Subset:  IM    
Cardiac Catheterization Laboratories, Department of Cardiology, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel.
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MeSH Terms
Angina, Unstable / complications
Angioplasty, Balloon / statistics & numerical data
Coronary Angiography / statistics & numerical data
Coronary Restenosis / complications,  therapy*
Diabetes Mellitus
Drug-Eluting Stents*
Follow-Up Studies
Graft Occlusion, Vascular / complications,  radiography,  therapy*
Myocardial Infarction / complications
Prospective Studies
Survival Analysis
Treatment Outcome

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