| Characterization of chromosomal aberrations in thymic MALT lymphoma. | |
| | |
MedLine Citation:
|
PMID: 22243778 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Mucosa-associated lymphoid tissue (MALT) lymphoma arising in the thymus is a rare disorder that shows a strong association with autoimmune disease. Several MALT-lymphoma-specific and -associated chromosomal abnormalities, including t(11;18), t(14;18), t(1;14), trisomy 3 and trisomy 18, are known to occur. The former translocation results in apoptosis inhibitor 2 gene (API2)-MALT lymphoma-associated translocation 1 (MALT1) fusion. In this study, we examined 14 cases of thymic MALT lymphomas for API2-MALT1 fusion using multiplex reverse transcription polymerase chain reaction and looked for trisomy 3, trisomy 18 and abnormalities of MALT1 and IGH genes using fluorescence in situ hybridization. Thymic MALT lymphoma cases had a high frequency of trisomy 3 (7/14 cases), a very low incidence of trisomy 18 (1/14) and no detectable MALT1-associated (0/13) or IGH-associated (0/13) gene abnormalities including t(11;18). A review of the literature showed that the pattern of chromosomal aberrations in thymic MALT lymphoma was similar to those of thyroid and salivary gland MALT lymphomas. Although frequently detected, trisomy 3 was not associated with any of the clinicopathological factors analyzed, suggesting that trisomy 3 may play a role in lymphoma development. In conclusion, the present study showed that thymic MALT lymphoma has a characteristic pattern of chromosomal aberrations that may be similar to those of other autoimmune-associated MALT lymphomas. |
| | |
Authors:
|
Satoru Kominato; Takahisa Nakayama; Fumihiko Sato; Seiji Yamada; Hongjing Xia; Yukio Fujiyoshi; Hideo Hattori; Hiroshi Inagaki |
Related Documents
:
|
17248838 - Partial dominance of ems-induced mutations affecting viability in drosophila melanogaster. 15582318 - Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. 226848 - Increased resistance to influenza as a possible source of heterozygote advantage in cys... 23548668 - Translocation t(5;18)(q35;q21) as a rare nonrandom abnormality in acute myeloid leukemia. 22215958 - Cytogenetic analysis of five hypostomus species (siluriformes, loricariidae). 15004738 - Microsatellite-based deletion bin system for the establishment of genetic-physical map ... |
Publication Detail:
|
Type: Journal Article Date: 2012-01-13 |
Journal Detail:
|
Title: Pathology international Volume: 62 ISSN: 1440-1827 ISO Abbreviation: Pathol. Int. Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9431380 Medline TA: Pathol Int Country: Australia |
Other Details:
|
Languages: eng Pagination: 93-8 Citation Subset: IM |
Copyright Information:
|
© 2011 The Authors. Pathology International © 2011 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
|
Department of Pathology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Histone H1 expression in human prostate cancer tissues and cell lines.
Next Document: Analysis of the pathological lesions of the lung in a mouse model of cutaneous infection with Strept...