Document Detail

Characterization of changes in leptin and leptin receptors in a rat model of preeclampsia.
MedLine Citation:
PMID:  16021089     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to determine the influence of reduced uteroplacental perfusion pressure on plasma leptin and placental leptin receptor expression in rats that develop hypertension in the third trimester of pregnancy. STUDY DESIGN: The ovarian arteries and abdominal aortae of pregnant Sprague-Dawley rats (n=9) were constricted surgically on day 14 of gestation and were matched with sham controls. Systolic blood pressure and weight were measured biweekly. Maternal plasma leptin levels, placental leptin receptor abundance, fetal number, fetal weight, and placental weight were determined. RESULTS: Reductions in perfusion pressure induced a significant decrease in maternal plasma leptin. Maternal systolic blood pressure and leptin receptor protein abundance was increased in the experimental group. Litter size and fetal and placental weight were significantly decreased in response to reduced perfusion pressure. CONCLUSION: Reduced uteroplacental perfusion pressure reduces litter size, fetal and placental weights, and maternal plasma leptin levels and increases placental expression of leptin receptors.
Cindy M Anderson; Faye Lopez; Hai-Ying Zhang; Kristin Pavlish; Joseph N Benoit
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  193     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-15     Completed Date:  2005-08-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-72     Citation Subset:  AIM; IM    
College of Nursing and Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks 58202, USA.
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MeSH Terms
Blood Pressure*
Fetal Weight
Leptin / blood*
Litter Size
Organ Size
Placenta / blood supply*,  metabolism,  pathology
Pre-Eclampsia / blood,  metabolism,  physiopathology*
Pregnancy, Animal / blood,  metabolism*
Rats, Sprague-Dawley
Receptors, Cell Surface / metabolism*
Receptors, Leptin
Uterus / blood supply*
Grant Support
Reg. No./Substance:
0/Leptin; 0/Receptors, Cell Surface; 0/Receptors, Leptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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