| Characterization of changes in leptin and leptin receptors in a rat model of preeclampsia. | |
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MedLine Citation:
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PMID: 16021089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to determine the influence of reduced uteroplacental perfusion pressure on plasma leptin and placental leptin receptor expression in rats that develop hypertension in the third trimester of pregnancy. STUDY DESIGN: The ovarian arteries and abdominal aortae of pregnant Sprague-Dawley rats (n=9) were constricted surgically on day 14 of gestation and were matched with sham controls. Systolic blood pressure and weight were measured biweekly. Maternal plasma leptin levels, placental leptin receptor abundance, fetal number, fetal weight, and placental weight were determined. RESULTS: Reductions in perfusion pressure induced a significant decrease in maternal plasma leptin. Maternal systolic blood pressure and leptin receptor protein abundance was increased in the experimental group. Litter size and fetal and placental weight were significantly decreased in response to reduced perfusion pressure. CONCLUSION: Reduced uteroplacental perfusion pressure reduces litter size, fetal and placental weights, and maternal plasma leptin levels and increases placental expression of leptin receptors. |
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Authors:
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Cindy M Anderson; Faye Lopez; Hai-Ying Zhang; Kristin Pavlish; Joseph N Benoit |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 193 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-15 Completed Date: 2005-08-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 267-72 Citation Subset: AIM; IM |
Affiliation:
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College of Nursing and Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks 58202, USA. cindyanderson@mail.und.nodak.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure* Female Fetal Weight Leptin / blood* Litter Size Organ Size Placenta / blood supply*, metabolism, pathology Pre-Eclampsia / blood, metabolism, physiopathology* Pregnancy Pregnancy, Animal / blood, metabolism* Rats Rats, Sprague-Dawley Receptors, Cell Surface / metabolism* Receptors, Leptin Uterus / blood supply* |
| Grant Support | |
ID/Acronym/Agency:
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NIDDK-51430/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 0/Receptors, Cell Surface; 0/Receptors, Leptin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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