| Characterization of cerebral microangiopathy using 3 Tesla MRI: correlation with neurological impairment and vascular risk factors. | |
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MedLine Citation:
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PMID: 11793450 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate whether clinical and neuropsychological impairment in cerebral small-vessel disease (CSVD) can be evaluated by means of morphological magnetic resonance imaging (MRI). MATERIALS AND METHODS: MRI at 3 Tesla in T2- and T1-weighted sequences was evaluated in 44 patients with cerebral microangiopathy, and 30 patients with combined cerebral micro- and macroangiopathy. The MR characteristics were correlated to clinical data, attentional impairment, and the patients' individual vascular risk factor profiles. Fifteen healthy age-matched control subjects participated in the study to assess MR signal changes in nonhypertensive elderly subjects. RESULTS: Patients and normal controls differed significantly in the extent of MR signal changes. A close relation between age, obesity, hypertension, and MR signal abnormalities was evident in all patients. Patients with pure CSVD additionally showed an association between their MR-defined severity of disease and their degree of neurological impairment, and their vascular risk score. In contrast, attentional impairment did not relate to the MR-defined severity of CSVD. CONCLUSION: MR signal changes in CSVD show a close relationship to some risk factors of individual patients. |
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Authors:
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Margret Hund-Georgiadis; Olaf Ballaschke; Rainer Scheid; David G Norris; D Yves von Cramon |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 15 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-01-16 Completed Date: 2002-02-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Wiley-Liss, Inc. |
Affiliation:
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Max-Planck Institute of Cognitive Neuroscience, Leipzig, Germany. hund@cns.mpg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Case-Control Studies Cerebrovascular Circulation / physiology Cerebrovascular Disorders / pathology*, physiopathology Female Humans Magnetic Resonance Imaging / methods* Male Microcirculation / physiology Middle Aged Neuropsychological Tests Risk Factors |
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