Document Detail

Characterization of cardiac remodeling in a large animal "one-kidney, one-clip" hypertensive model.
MedLine Citation:
PMID:  20367547     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study is to characterize cardiac remodeling in a large animal model of hypertension. METHODS: 23 sheep were subjected to unilateral nephrectomy followed by clamping of the remaining renal artery to 60% ("one kidney-one clip", 1K1C) 3 weeks later. Blood pressure (BP) was monitored invasively over 73+/-28 days. Cardiac function was assessed with magnetic resonance imaging and compared with 12 size-matched controls. Detailed atrial histopathological analysis was performed. RESULTS: In the 1K1C animals, BP rose from baseline to reach a plateau by 4 weeks (systolic BP: 107+/-12 to 169+/-27, diastolic BP: 71+/-10 to 118+/-29 mmHg, both p< 0.0001); cardiac hypertrophy was significant when compared with controls with increased left ventricular weight [left ventricular (LV)/body wt: 2.7+/-0.5 vs 2.1+/-0.2 g/kg, p=0.01] as well as bi-atrial enlargement (right atrial, RA: 22.9+/-4.9 vs 15.7+/-2.8g, p=0.003; left atrial, LA: 35.5+/-6.7 vs 20.9+/-4.1g, p=0.0003); cardiac magnetic imaging demonstrated significantly increased LA volumes (end-diastolic volume: 42.9+/-6.8 vs 28.7+/-6.3 ml, p< 0.0001) and reduced LA ejection fraction (24.1+/-3.6 vs 31.6+/-3.0%, p=0.001) while LV function was relatively preserved (42.3+/-4.7 vs 46.4+/-4.1%, p=0.1); degeneration and necrosis of atrial myocytes were evident with increased atrial lymphocytic infiltration and interstitial fibrosis. CONCLUSIONS: The ovine 1K1C model produces reliable and reproducible hypertension with demonstrable cardiac end-organ damage.
Dennis H Lau; Lorraine Mackenzie; Arumuga Rajendram; Peter J Psaltis; Douglas R Kelly; Peter Spyropoulos; Yuan Zhang; Santosh A Olakkengil; Christine H Russell; Anthony G Brooks; Randall J Faull; David A Saint; Darren J Kelly; M Mohan Rao; Stephen G Worthley; Prashanthan Sanders
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood pressure     Volume:  19     ISSN:  1651-1999     ISO Abbreviation:  Blood Press.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-06     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  England    
Other Details:
Languages:  eng     Pagination:  119-25     Citation Subset:  IM    
Cardiovascular Research Centre, Departments of Cardiology and Renal Medicine, Royal Adelaide Hospital, University of Adelaide, Australia.
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MeSH Terms
Blood Pressure
Creatine / blood
Disease Models, Animal
Heart / physiopathology*
Heart Atria / physiopathology
Hypertension / blood,  physiopathology*
Kidney / pathology
Magnetic Resonance Imaging
Ventricular Function, Left / physiology
Ventricular Remodeling / physiology*
Reg. No./Substance:

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