Document Detail


Characterization of canine platelet adhesion to extracellular matrix proteins.
MedLine Citation:
PMID:  20659807     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Canine platelets have been extensively studied but little is known about specific aspects such as adhesion. Platelet adhesion is a critical step during haemostasis and thrombosis as well as during inflammatory and immunopathogenic responses. The aim of this study was to evaluate the adhesive properties of canine platelets using fibrinogen and collagen as substrates immobilized on plates. Adhesion was monitored for 120min and the effect of adenosine 5'-diphosphate (ADP) was assayed. The results showed that canine platelets displayed good adhesion activity that was significantly time-dependent. Moreover, ADP was able to enhance platelet adhesion in a dose-dependent manner. The findings aid knowledge of the adhesion process and suggest a specific role of surface platelet receptors in mediating the interaction with extracellular matrix proteins.
Authors:
Alessandra Pelagalli; Maria Elena Pero; Vincenzo Mastellone; Anna Cestaro; Simona Signoriello; Pietro Lombardi; Luigi Avallone
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Publication Detail:
Type:  Journal Article     Date:  2010-07-24
Journal Detail:
Title:  Veterinary journal (London, England : 1997)     Volume:  189     ISSN:  1532-2971     ISO Abbreviation:  Vet. J.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706281     Medline TA:  Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  115-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Biological Structures, Functions and Technologies, Faculty of Veterinary Medicine, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, Italy.
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