Document Detail

Characterization of arginase 1 gene polymorphisms in the Algerian population and association with blood pressure.
MedLine Citation:
PMID:  19303401     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: (i) To characterize the polymorphism of arginase 1 (ARG1), a new candidate gene in coronary heart disease (CHD), in the Algerian population; (ii) To evaluate the effect of common ARG1 single nucleotide polymorphisms (SNPs) on blood pressure (BP) values; and (iii) To compare the data with those previously obtained in French populations. METHODS: Eleven ARG1 SNPs selected from databases were characterized in a representative sample of 117 Algerian and 92 French males free of CHD. Relevant SNPs for association studies with BP were selected on the basis of their allele frequencies and pairwise linkage disequilibrium. RESULTS: ARG1 allele frequencies and haplotype distribution significantly differed between Algerian and French subjects. The rs2781667C/T polymorphism was associated with decreased systolic BP in Algerian subjects. This association contrasted with previous data we reported in the French population. The discrepancy would be explained by the difference in haplotype distribution between Algerian and French subjects. CONCLUSION: These data support the role of ARG1 in vascular pathophysiology, but the functional mutations remain to be identified.
Djabaria Meroufel; Julie Dumont; Sounnia Médiène-Benchekor; Soraya Benhammamouch; Pierre Ducimetière; Dominique Cottel; Michèle Montaye; Philippe Amouyel; Thierry Brousseau
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-19
Journal Detail:
Title:  Clinical biochemistry     Volume:  42     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-15     Completed Date:  2009-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1178-82     Citation Subset:  IM    
Inserm, U744, Lille, France.
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MeSH Terms
African Continental Ancestry Group / genetics*
Arginase / genetics*
Blood Pressure / genetics*
Coronary Disease / enzymology,  genetics
European Continental Ancestry Group / genetics
Gene Frequency
Genetic Predisposition to Disease
Middle Aged
Polymorphism, Genetic*
Polymorphism, Single Nucleotide / genetics
Reg. No./Substance:

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