| Characterization of anti-myocardial autoantibodies in Japanese patients with dilated cardiomyopathy. | |
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MedLine Citation:
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PMID: 11665790 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Few previous reports have comprehensively screened all the anti-myocardial autoantibodies (AMCA) in relation to other clinical profiles in patients with idiopathic dilated cardiomyopathy (IDC), so the present study used both immunohistochemistry (FITC) and immunoblotting (IB) for screening patients with IDC in order to characterize the clinical significance of AMCA. Sera were collected from 100 patients with IDC and age-matched 100 healthy control subjects (CTL). For FITC, an unfixed frozen section of human myocardium was used for the standard indirect immunofluorescence; for IB, total cardiac homogenates of the same myocardium were blotted to serum at 2 sets of dilution (1:200 and 1:10,000). The positive rates of AMCA detection for each method were as follows (IDC vs CTL); 39% vs 6% for FITC, 38% vs 4% for IB (1:200), and 10% vs 0% for IB (1:10,000). Fifty-nine patients with IDC and 8 CTL were positive for AMCA by either method, and 18 patients with IDC and 2 CTL were positive for AMCA by both methods. IB-positivity at 1:200 was an independent predictor by multiple logistic regression analysis of non-sustained ventricular tachycardias as well as left ventricular end-diastolic diameter and plasma norepinephrine concentration. |
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Authors:
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A Baba; T Yoshikawa; M Chino; A Murayama; K Mitani; S Nakagawa; I Fujii; M Shimada; M Akaishi; S Iwanaga; Y Asakura; K Fukuda; H Mitamura; S Ogawa; |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Japanese circulation journal Volume: 65 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-22 Completed Date: 2002-11-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: Australia |
Other Details:
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Languages: eng Pagination: 867-73 Citation Subset: IM |
Affiliation:
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Department of Medicine, Kitasato Institute Hospital, Tokyo, Japan. baba-a@kitasato.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Autoantibodies* / analysis* Cardiomyopathy, Dilated / etiology, immunology* Case-Control Studies Female Humans Immunoblotting Immunohistochemistry Japan Male Middle Aged Myocardium / immunology* Odds Ratio Tachycardia, Ventricular / immunology |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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