| Characterization of the amyloid fibril from primary localized cutaneous nodular amyloidosis associated with Sjögren's syndrome. | |
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MedLine Citation:
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PMID: 8075437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare disease, and its pathogenesis of amyloid deposition is still unknown. OBJECTIVE: The purpose of this study was to know the origin of amyloid in PLCNA. METHODS: Water-soluble amyloid fibrils were isolated from the skin and resolved on SDS-PAGE, then subjected to immunoblot analysis. RESULTS: The major amyloid fibril protein was a 29-kD peptide which reacted with both anti-lambda- and anti-kappa-light-chain antibodies. CONCLUSION: Amyloids in this particular case of PLCNA are derived from the polyclonal immunoglobulin light chain and some cases of PLCNA could be reactive diseases rather than neoplastic ones. |
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Authors:
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T Inazumi; M Hakuno; H Yamada; M Tanaka; W Naka; S Tajima; T Harada; T Nishikawa |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Dermatology (Basel, Switzerland) Volume: 189 ISSN: 1018-8665 ISO Abbreviation: Dermatology (Basel) Publication Date: 1994 |
Date Detail:
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Created Date: 1994-10-04 Completed Date: 1994-10-04 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9203244 Medline TA: Dermatology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 125-8 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Urawa Municipal Hospital, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amyloid
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metabolism* Amyloidosis / etiology, metabolism*, pathology Biopsy Female Humans Immunohistochemistry Middle Aged Sjogren's Syndrome / complications, metabolism*, pathology Skin / pathology Skin Diseases / etiology, metabolism*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Amyloid; 0/amyloid fibril protein AL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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