Document Detail


Characterization of the amyloid fibril from primary localized cutaneous nodular amyloidosis associated with Sjögren's syndrome.
MedLine Citation:
PMID:  8075437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare disease, and its pathogenesis of amyloid deposition is still unknown. OBJECTIVE: The purpose of this study was to know the origin of amyloid in PLCNA. METHODS: Water-soluble amyloid fibrils were isolated from the skin and resolved on SDS-PAGE, then subjected to immunoblot analysis. RESULTS: The major amyloid fibril protein was a 29-kD peptide which reacted with both anti-lambda- and anti-kappa-light-chain antibodies. CONCLUSION: Amyloids in this particular case of PLCNA are derived from the polyclonal immunoglobulin light chain and some cases of PLCNA could be reactive diseases rather than neoplastic ones.
Authors:
T Inazumi; M Hakuno; H Yamada; M Tanaka; W Naka; S Tajima; T Harada; T Nishikawa
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  189     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  1994  
Date Detail:
Created Date:  1994-10-04     Completed Date:  1994-10-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  125-8     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Urawa Municipal Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amyloid / metabolism*
Amyloidosis / etiology,  metabolism*,  pathology
Biopsy
Female
Humans
Immunohistochemistry
Middle Aged
Sjogren's Syndrome / complications,  metabolism*,  pathology
Skin / pathology
Skin Diseases / etiology,  metabolism*,  pathology
Chemical
Reg. No./Substance:
0/Amyloid; 0/amyloid fibril protein AL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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