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Characterization of alpha-amino-n-butyric acid correlations in sepsis.
MedLine Citation:
PMID:  22061040     Owner:  NLM     Status:  In-Data-Review    
Little information is available on the patterns of changes and significance of plasma alpha-amino-n-butyric acid (ABA, μmol/L) in various conditions, particularly in sepsis. This study has been performed to assess the patterns of correlation among ABA, other amino acids, and other variables in a group of septic patients with various degrees of illness. More than 400 determinations of ABA, other amino acids, and simultaneously collected blood variables were obtained in 17 patients with sepsis. The distribution of ABA was characterized by the clustering of most measurements within the normal range (<41 μmol/L), with the spreading of abnormally increased values up to 151 μmol/L. Abnormal increases in ABA were related directly to alanine, serine, tyrosine, histidine, proline, threonine, glycine, glutamine, cysteine, lysine, cystathionine, leucine, valine, phenylalanine, arginine, and citrulline (r(2) from 0.86 to 0.32) and related inversely to aspartate, taurine, and phosphoethanolamine (r(2) from 0.62 to 0.50) (P < 0.001 for all). Furthermore, increased ABA was correlated with increasing total aminoacidemia, lactate, neutrophil concentration, creatinine, ammonia, osmolarity, glucose, and bilirubin and with decreasing AA Fischer ratio and peripheral O(2) extraction (r(2) from 0.87 to 0.16) (P < 0.001 for all). High ABA was also associated with low cholesterol, taurine, and platelet count, and with high 3-methylhistidine (partly anticipating the increase), high blood urea nitrogen, and pulmonary shunt (P < 0.001 for all). Finally, high ABA was related to the worsening of sepsis-related organ failure assessment score (SOFA score) and of most plasma AA clearances (P < 0.001 for all). Abnormally increased ABA may signal and partly anticipate the transition to an extreme derangement of septic metabolic patterns, characterized by the worsening of protein hypercatabolism with hyperaminoacidemia and by signs of impaired hepatic amino acid metabolism and oxidative metabolism. Increased ABA may represent an additional landmark of transition to extreme illness, compelling the need for the aggressive resolution of sepsis.
Carlo Chiarla; Ivo Giovannini; John H Siegel
Publication Detail:
Type:  Journal Article     Date:  2011-07-18
Journal Detail:
Title:  Translational research : the journal of laboratory and clinical medicine     Volume:  158     ISSN:  1878-1810     ISO Abbreviation:  Transl Res     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101280339     Medline TA:  Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  328-33     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
Department of Surgical Sciences, CNR-IASI Center for the Pathophysiology of Shock, Catholic University of the Sacred Heart School of Medicine, Rome, Italy; New Jersey Medical School, UMDNJ, Newark, NJ.
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