Document Detail


Characterization of acute hereditary angioedema attacks during pregnancy and breast-feeding and their treatment with C1 inhibitor concentrate.
MedLine Citation:
PMID:  20471627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of the study was to investigate the rates and characteristics of hereditary angioedema (HAE) attacks associated with pregnancy, delivery, and the postpartum period and their treatment with C1 esterase inhibitor (INH) concentrate. STUDY DESIGN: This was an observational study including 22 women with type I HAE, with data collected before, during, and after 35 pregnancies (37 children) based on patient diaries, interviews, and case report forms. RESULTS: In 83% of pregnancies, attack rates increased during pregnancy; highest mean rates occurred in the second and third trimesters. C1-INH concentrate effectively controlled attacks and was safe for mothers and children. Low-plasma C1-INH activity during pregnancy tended to be associated with an increased chance of giving birth to a child with HAE. CONCLUSION: Increased attack rates during pregnancy in women with HAE are well controlled with C1-INH concentrate, indicating the clear benefit of integrating the availability of C1-INH concentrate into the management plan for these women during pregnancy and delivery.
Authors:
Inmaculada Martinez-Saguer; Eva Rusicke; Emel Aygören-Pürsün; Christine Heller; Thomas Klingebiel; Wolfhart Kreuz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-14
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  203     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2010-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  131.e1-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 Mosby, Inc. All rights reserved.
Affiliation:
Department of Hematology, Center of Pediatrics III, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany. inmaculada.martinez-saguer@kgu.de
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Angioedemas, Hereditary / diagnosis,  drug therapy*
Breast Feeding
Cohort Studies
Complement C1 Inhibitor Protein / administration & dosage*
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Follow-Up Studies
Genetic Diseases, Inborn / diagnosis*,  epidemiology
Gestational Age
Humans
Infant, Newborn
Neonatal Screening
Postpartum Period
Pregnancy
Pregnancy Complications, Hematologic / diagnosis,  drug therapy*
Pregnancy Outcome*
Retrospective Studies
Risk Assessment
Severity of Illness Index
Treatment Outcome
Chemical
Reg. No./Substance:
0/Complement C1 Inhibitor Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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