Document Detail


Characterization of an acid-inducible sulfatase in Salmonella enterica serovar typhimurium.
MedLine Citation:
PMID:  23315743     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sulfatases of enteric bacteria can provide access to heavily sulfated mucosal glycans. In this study, we show that aslA (STM0084) of Salmonella enterica serovar Typhimurium LT2 encodes a sulfatase that requires mildly acidic pH for its expression and activity. AslA is not regulated by sulfur compounds or tyramine but requires the EnvZ-OmpR and PhoPQ regulatory systems, which play an important role in pathogenesis.
Authors:
Seema Das; Swati Singh; Michael McClelland; Steven Forst; Prasad Gyaneshwar
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-01-11
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  79     ISSN:  1098-5336     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-27     Completed Date:  2013-08-06     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2092-5     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, University of Wisconsin Milwaukee, Milwaukee, Wisconsin, USA.
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MeSH Terms
Descriptor/Qualifier:
Acids / metabolism*
Bacterial Proteins / biosynthesis*,  genetics*
Gene Expression Regulation, Bacterial
Hydrogen-Ion Concentration
Salmonella typhimurium / enzymology*,  genetics,  metabolism
Sulfatases / biosynthesis*,  genetics*
Transcriptional Activation*
Grant Support
ID/Acronym/Agency:
AI039557/AI/NIAID NIH HHS; AI052237/AI/NIAID NIH HHS; AI073971/AI/NIAID NIH HHS; AI075093/AI/NIAID NIH HHS; AI077645/AI/NIAID NIH HHS; AI083646/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Acids; 0/Bacterial Proteins; EC 3.1.6.-/Sulfatases
Comments/Corrections

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