| Characterization of X-tropic endogenous retrovirus-specific RNA uninfected tissues and lymphosarcoma of BALB/c mice. | |
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MedLine Citation:
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PMID: 6255075 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Analysis of endogenous X-tropic BALB/c retrovirus-specific RNAs in a BALB/c mouse tissue containing mostly non-driving cells (liver), in two normal tissues having significant proportions of dividing cells (20-h regenerating liver and 12-day embryo) and in cells of a lymphosarcoma of BALB/c mice were carried out by determining the extent to which the RNAs from these tissues hybridized to the virus 3H-cDNA probe and by their relative sedimentation values in a sucrose gradient. RNAs from 20-h regenerating liver, 12-day embryo and lymphosarcoma, each containing a significant proportion of proliferating cells, showed 8 to 21 % higher hybridization values than normal liver RNA. Differences in the exact size classes of virus-specific RNAs and, in their relative proportions were found to exist in the four different tissue types examined and no correlation between a specific RNA size-profile and the proliferating activity of a tissue could be detected. |
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Authors:
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B B Mukherjee; P M Mobry; R N Vincent |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of general virology Volume: 49 ISSN: 0022-1317 ISO Abbreviation: J. Gen. Virol. Publication Date: 1980 Aug |
Date Detail:
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Created Date: 1981-02-26 Completed Date: 1981-02-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077340 Medline TA: J Gen Virol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 411-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Centrifugation, Density Gradient Embryo, Mammalian / microbiology Liver / microbiology Lymphoma, Non-Hodgkin / microbiology* Mice Mice, Inbred BALB C / microbiology* Nucleic Acid Hybridization RNA, Viral / isolation & purification* Retroviridae* Sarcoma, Experimental / microbiology* |
| Chemical | |
Reg. No./Substance:
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0/RNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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