Document Detail

Characterization of X-tropic endogenous retrovirus-specific RNA uninfected tissues and lymphosarcoma of BALB/c mice.
MedLine Citation:
PMID:  6255075     Owner:  NLM     Status:  MEDLINE    
Analysis of endogenous X-tropic BALB/c retrovirus-specific RNAs in a BALB/c mouse tissue containing mostly non-driving cells (liver), in two normal tissues having significant proportions of dividing cells (20-h regenerating liver and 12-day embryo) and in cells of a lymphosarcoma of BALB/c mice were carried out by determining the extent to which the RNAs from these tissues hybridized to the virus 3H-cDNA probe and by their relative sedimentation values in a sucrose gradient. RNAs from 20-h regenerating liver, 12-day embryo and lymphosarcoma, each containing a significant proportion of proliferating cells, showed 8 to 21 % higher hybridization values than normal liver RNA. Differences in the exact size classes of virus-specific RNAs and, in their relative proportions were found to exist in the four different tissue types examined and no correlation between a specific RNA size-profile and the proliferating activity of a tissue could be detected.
B B Mukherjee; P M Mobry; R N Vincent
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of general virology     Volume:  49     ISSN:  0022-1317     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1981-02-26     Completed Date:  1981-02-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  411-6     Citation Subset:  IM    
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MeSH Terms
Centrifugation, Density Gradient
Embryo, Mammalian / microbiology
Liver / microbiology
Lymphoma, Non-Hodgkin / microbiology*
Mice, Inbred BALB C / microbiology*
Nucleic Acid Hybridization
RNA, Viral / isolation & purification*
Sarcoma, Experimental / microbiology*
Reg. No./Substance:
0/RNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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