Document Detail

Characterization of WC1 co-receptors on functionally distinct subpopulations of ruminant gamma delta T cells.
MedLine Citation:
PMID:  16828467     Owner:  NLM     Status:  MEDLINE    
WC1 molecules are implicated in augmenting cellular activation as well as inducing cell cycle arrest of gammadelta T cells. Since WC1 is a large multigene family differences in outcome could result from modulation of different WC1 molecules. To further investigate this family of molecules, peripheral blood WC1(+) gammadelta T cell subpopulations were evaluated by 2-D Western blotting and RT-PCR. We found 13 cDNA intracytoplasmic tail sequences with differences in signaling motifs among them and at least 20 biochemically distinguishable WC1 spots associated with cell membranes, with some in lipid rafts. An understanding of the diversity of 2-D spots could not be resolved by evaluating T cell clones, removing sialyated carbohydrates or blotting with anti-WC1.1 or anti-WC1.2-specific antibodies. Nevertheless, while the major gammadelta T cell subpopulations in blood (WC1.1(+)/WC1.2(-) and WC1.2(+)/WC1.1(-)) both had complex 2-D patterns, virtually all spots associated with WC1.2(+)/WC1.1(-) cells bore the WC1.2 epitope, distinguishing them from the WC1.1(+) cells.
Aric N Rogers; Denille G Vanburen; Baixiang Zou; Kevin K Lahmers; Carolyn T A Herzig; Wendy C Brown; Janice C Telfer; Cynthia L Baldwin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-07-07
Journal Detail:
Title:  Cellular immunology     Volume:  239     ISSN:  0008-8749     ISO Abbreviation:  Cell. Immunol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-07-17     Completed Date:  2006-08-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1246405     Medline TA:  Cell Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-61     Citation Subset:  IM    
Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/DQ153067;  DQ153068;  DQ153069;  DQ153070;  DQ153071;  DQ153072;  DQ153073;  DQ153074;  DQ153077;  DQ153078
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MeSH Terms
Amino Acid Sequence
Cell Membrane / immunology,  metabolism
Cells, Cultured
Clone Cells
Cytoplasm / immunology,  metabolism
Membrane Glycoproteins / chemistry*,  genetics
Molecular Sequence Data
Receptors, Antigen, T-Cell, gamma-delta / chemistry*,  metabolism*
T-Lymphocyte Subsets / immunology,  metabolism*
Grant Support
Reg. No./Substance:
0/DMBT1 protein, Bos taurus; 0/Membrane Glycoproteins; 0/Receptors, Antigen, T-Cell, gamma-delta

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