Document Detail

Characterization of T wave alternans with ambulatory electrocardiography.
MedLine Citation:
PMID:  18077775     Owner:  NLM     Status:  MEDLINE    
T wave alternans (TWA) is a marker of ventricular electrical instability considered to be predictive for ventricular tachyarrhythmias. Techniques have been developed to detect TWA at the microv level as a method for arrhythmia risk stratification of persons at high risk for sudden cardiac death. Currently, TWA is typically calculated using spectral analysis, whereby TWA is presumed to assume characteristics of stationarity. In contrast, a nonspectral method known as modified moving average analysis is purported to detect transient TWA that would not be observed using a spectral approach. The purpose of this pilot study work was to establish the basic TWA signal properties obtained with a device developed by GE Medical Systems using a descriptive, correlational study design. Ambulatory electrocardiography (AECG) recordings (N = 24) were digitized and processed, and TWA was calculated via the modified moving average technique. Findings showed that noise was positively correlated with TWA in AECG channel 1 (r = .899, p < .01) and AECG channel 2 (r = .758, p < .01). However, no significant difference (p = .237) was observed in TWA values between the AECG channels. A weak positive correlation was found between TWA and heart rate, expressed as beats per min (r = .262). Heart rate mildly predicted TWA (R = 0.34). Nonstationarity was evaluated by testing for trend and randomness. TWA values measured from AECG recordings were found to be influenced moderately by noise and minimally by heart rate and lead placement.
Margaret B Harvey; Jack W Buchanan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological research for nursing     Volume:  9     ISSN:  1099-8004     ISO Abbreviation:  Biol Res Nurs     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-13     Completed Date:  2008-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815758     Medline TA:  Biol Res Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-30     Citation Subset:  IM; N    
University of Tennessee Health Science Center, Memphis, TN 38103, USA.
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MeSH Terms
Electrocardiography, Ambulatory*
Pilot Projects
Comment In:
Biol Res Nurs. 2008 Apr;9(4):269-70; discussion 271   [PMID:  18411490 ]

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