Document Detail


Characterization of Radiofrequency Ablation Lesion Development Based on Simulated and Measured Intracardiac Electrograms.
MedLine Citation:
PMID:  24816474     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Radiofrequency ablation (RFA) therapy is the gold standard in interventional treatment of many cardiac arrhythmias. A major obstacle are non transmural lesions, leading to recurrence of arrhythmias. Recent clinical studies have suggested intracardiac electrogram (EGM) criteria as a promising marker to evaluate lesion development. Seeking for a deeper understanding of underlying mechanisms, we established a simulation approach for acute RFA lesions. Ablation lesions were modeled by a passive necrotic core surrounded by a borderzone with properties of heated myocardium. Herein, conduction velocity and electrophysiological properties were altered. We simulated EGMs during RFA to study the relation between lesion formation and EGM changes using the bidomain model. Simulations were performed on a three dimensional setup including a geometrically detailed representation of the catheter with highly conductive electrodes. For validation, EGMs recorded during RFA procedures in five patients were analyzed and compared to simulation results. Clinical data showed major changes in the distal unipolar EGM. During RFA, the negative peak amplitude decreased up to 104% and maximum negative deflection was up to 88% smaller at the end of the ablation sequence. These changes mainly occurred in the first 10 s after ablation onset. Simulated unipolar EGM reproduced the clinical changes, reaching up to 83% negative peak amplitude reduction and 80% decrease in maximum negative deflection for transmural lesions. In future work, the established model may enable the development of further EGM criteria for transmural lesions even for complex geometries in order to support clinical therapy.
Authors:
Matthias Keller; Steffen Schuler; Mathias Wilhelms; Gustavo Lenis; Gunnar Seemann; C Schmitt; Olaf Doessel; Armin Luik
Related Documents :
24581284 - Diverse arachnoid cyst morphology indicates different pathophysiological origins.
21177214 - Soft tissue high grade myoepithelial carcinoma with round cell morphology: report of a ...
1727244 - Pedunculated club-shaped swelling in the nostril.
11092274 - A case of vesiculo-bullous darier's disease associated with bipolar psychiatric disorder.
9637464 - Treatment strategy for patients with cystic lesions mimicking a liver tumor: a recent 1...
24974904 - Mortality due to a retained circle hook in a longfin mako shark isurus paucus (guitart-...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-07
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  -     ISSN:  1558-2531     ISO Abbreviation:  IEEE Trans Biomed Eng     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Tissue Doppler Imaging Optical Flow (TDIOF): A Combined B-Mode and Tissue Doppler Approach for Cardi...
Next Document:  An optimized HPLC/MS/MS method for quantification of excitatory amino acids in rat hippocampus and i...