Document Detail

Characterization and Optimization of Ultrasound-induced Molecular Delivery In Vivo.
MedLine Citation:
PMID:  18530150     Owner:  NLM     Status:  In-Data-Review    
Current treatments of neurological and neurodegenerative diseases are limited due to the lack of a truly noninvasive, transient, and regionally selective brain drug delivery method. The brain is particularly difficult to deliver drugs to because of the blood-brain barrier (BBB). Over the past few years, we have been developing methods that combine Focused Ultrasound (FUS) and microbubbles in order to noninvasively, locally and transiently open the BBB so as to treat neurodegenerative diseases. In this paper, we will focus on the characterization of the type of molecular delivery that can be induced through the opened BBB. More specifically, we willl characterize important properties of the BBB opening such as its size and permeability using fluorescence and MR imaging techniques, respectively. The role of the microbubble type, size and concentration on the BBB diffusion properties, its reversibility and the pressure threshold for the opening will also be described in vivo. Finally, results will be shown in both non-transgenic (normal) and transgenic (Alzheimer's) mice in order to determine the variability of the properties of the opened BBB in the presence and absence of disease.
Elisa Konofagou; James Choi; Shougang Wang; Barclay Morrison; Mark Borden
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  123     ISSN:  1520-8524     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-06-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3216     Citation Subset:  IM    
Dept. of Biomedical Engineering, Columbia Univ., 351 Engineering Terrace MC 8904, 1210 Amsterdam Ave., New York, NY 10027, USA,
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