Document Detail


Characterization of Ngef, a novel member of the Dbl family of genes expressed predominantly in the caudate nucleus.
MedLine Citation:
PMID:  10777665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have identified Ngef as a novel member of the family of Dbl genes. Many members of this family have been shown to function as guanine nucleotide exchange factors for the Rho-type GTPases. Ngef is predominantly expressed in brain, with the strongest signal in the caudate nucleus, a region associated with the control of movement. Ngef contains a translated trinucleotide repeat, a polyglutamic acid stretch interrupted by a glycine. We have localized the Ngef gene to mouse chromosome 1 and the human homologue of Ngef to human chromosome 2q37. We have shown in preliminary experiments that Ngef has transforming potential in cell culture and is able to induce tumors in nude mice.
Authors:
N R Rodrigues; A M Theodosiou; M A Nesbit; L Campbell; A T Tandle; D Saranath; K E Davies
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genomics     Volume:  65     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-06-05     Completed Date:  2000-06-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-61     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Affiliation:
Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, United Kingdom.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AJ238898;  AJ238899
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MeSH Terms
Descriptor/Qualifier:
3T3 Cells
Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
Caudate Nucleus / metabolism*
Chromosome Mapping
Chromosomes, Human, Pair 2 / genetics
DNA, Complementary / chemistry,  genetics,  isolation & purification
Gene Expression
Guanine Nucleotide Exchange Factors
Humans
In Situ Hybridization, Fluorescence
Mice
Mice, Nude
Molecular Sequence Data
Neoplasms, Experimental / genetics,  pathology
Proto-Oncogene Proteins / genetics*
RNA, Messenger / genetics,  metabolism
Sequence Alignment
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Tissue Distribution
Chemical
Reg. No./Substance:
0/DNA, Complementary; 0/Guanine Nucleotide Exchange Factors; 0/MCF2 protein, human; 0/Mcf2 protein, mouse; 0/Proto-Oncogene Proteins; 0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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