Document Detail


Characterization of HIV type 1 reverse transcriptase mutations in infants infected by mothers who received peripartum nevirapine prophylaxis in Jos, Nigeria.
MedLine Citation:
PMID:  18160018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was carried out to characterize HIV-1 reverse transcriptase (RT) mutations in vertically infected infants in Jos, Nigeria. DNA was extracted from peripheral blood mononuclear cells of 102 infants, aged 0 to 6 months, born to HIV-1-infected mothers who had received peripartum single-dose nevirapine prophylaxis. PCR-based diagnosis revealed that 14 infants (13.7%) were infected with HIV-1. Phylogenetic analyses of RT revealed wide viral diversity, with CRF02_AG, subtype G, subsubtype A3, CRF06_cpx, and a subtype D recombinant present in the population. Four of 13 (31%) infants had NNRTI resistance mutations--V179I (2 infants), Y181C, and V179E. Intriguingly, subtype G sequences did not have NNRTI mutations but rather carried a Q207N mutation, which may undergo negative selection under drug pressure. Our data suggest wide diversity for vertically transmitted HIV-1 viruses in Nigeria and highlight the potential significance of transmitting rare mutations in subtype G.
Authors:
Akinyemi I Ojesina; Christopher Mullins; Godwin Imade; Jay Samuels; Jean-Louis Sankalé; Sunday Pam; Solomon Sagay; John Idoko; Phyllis J Kanki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  23     ISSN:  0889-2229     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-27     Completed Date:  2008-03-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1587-92     Citation Subset:  IM; X    
Affiliation:
Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, Massachusetts 02115.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/EF394306;  EF394307;  EF394308;  EF394309;  EF394310;  EF394311;  EF394312;  EF394313;  EF394314;  EF394315;  EF394316;  EF394317;  EF394318;  EF394319
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Anti-HIV Agents / therapeutic use
Female
HIV Infections / drug therapy*,  prevention & control,  transmission,  virology
HIV Reverse Transcriptase / chemistry,  genetics*
HIV-1 / enzymology,  genetics*
Humans
Infant
Infectious Disease Transmission, Vertical / prevention & control
Molecular Sequence Data
Mutation*
Nevirapine / therapeutic use*
Nigeria
Phylogeny
Pregnancy
Pregnancy Complications, Infectious / drug therapy*,  virology
Recombination, Genetic
Reverse Transcriptase Inhibitors / therapeutic use*
Sequence Alignment
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Reverse Transcriptase Inhibitors; 129618-40-2/Nevirapine; EC 2.7.7.-/reverse transcriptase, Human immunodeficiency virus 1; EC 2.7.7.49/HIV Reverse Transcriptase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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