| Characterization of frequency-dependent responses of the vascular system to repetitive vibration. | |
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MedLine Citation:
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PMID: 20523237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The current frequency weighting proposed in the International Standards Organization-5349 standard may underestimate the risk of injury associated with exposure to vibration >100 Hz. The goal of this study was to assess the frequency-dependent responses of the peripheral vascular system to repeated bouts of vibration. METHODS: The effects of exposure to vibration at 62.5, 125, or 250 Hz (constant acceleration of 49 m/s2) on vascular morphology, oxidative stress, inflammation, and gene expression were examined in the ventral tail artery of rats. RESULTS: Vascular responses indicative of dysfunction (eg, remodeling and oxidative activity) became more pronounced as the frequency of the exposure increased. CONCLUSION: Exposure to vibration frequencies that induce the greatest stress and strain on the tail (ie, >100 Hz) result in vascular changes indicative of dysfunction. |
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Authors:
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Kristine Krajnak; G Roger Miller; Stacey Waugh; Claud Johnson; Shengqiao Li; Michael L Kashon |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine Volume: 52 ISSN: 1536-5948 ISO Abbreviation: J. Occup. Environ. Med. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504688 Medline TA: J Occup Environ Med Country: United States |
Other Details:
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Languages: eng Pagination: 584-94 Citation Subset: IM |
Affiliation:
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Engineering and Controls Technology Branch, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA. ksk1@cdc.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / pathology, physiopathology Gene Expression Profiling Interleukin-1beta / analysis Interleukin-6 / analysis Male Peripheral Vascular Diseases / etiology*, pathology, physiopathology Rats Rats, Sprague-Dawley Tail Vibration / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1beta; 0/Interleukin-6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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