Document Detail

Characterization of fatty acid profile in the liver of SHR/NDmcr-cp (cp/cp) rats, a model of the metabolic syndrome.
MedLine Citation:
PMID:  22293348     Owner:  NLM     Status:  MEDLINE    
The fatty acid profile of hepatic lipid in spontaneously hypertensive rats (SHR)/NDmcr-cp (cp/cp) rats (SHR/NDcp), which offer an animal model of the metabolic syndrome, was characterized by comparing those in Wistar Kyoto rats (WKY), SHR, stroke-prone spontaneously hypertensive rats (SHRSP) and SHR/NDmcr-cp (+/+) rats (SHR/ND+) . Hierarchical clustering analysis revealed that SHR/NDcp and the other four strains and/or substrains of rats were clearly disparate in fatty acid profile of hepatic lipid and that the disparity observed was due to the drastic increases in the mass of monounsaturated fatty acids, especially palmitoleic acid and oleic acid, in the liver of SHR/NDcp. Activities of stearoyl-CoA desaturase (SCD) and palmitoyl-CoA chain elongase in hepatic microsomes of SHR/NDcp were markedly higher than those of WKY, SHR, SHRSP and SHR/ND+. Activities of palmitoleoyl-CoA chain elongase in the liver of SHR/NDcp were also higher, but to a lesser extent. mRNA levels of SCD1 and elongation of very long-chain fatty acids (Elovl6), but not Elovl5, in the liver of SHR/NDcp were remarkably higher than those of the other four groups of rats. These results suggest that the enhanced expressions of SCD1 and Elovl6 induced abnormalities in fatty acid profile in the liver of SHR/NDcp.
Shizuyo Tanaka; Yurie Yagi; Tohru Yamazaki; Atsushi Mitsumoto; Daisuke Kobayashi; Naomi Kudo; Yoichi Kawashima
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  35     ISSN:  1347-5215     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-01     Completed Date:  2012-07-02     Revised Date:  2012-08-07    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  184-91     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
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MeSH Terms
Acetyltransferases / genetics
Carrier Proteins / metabolism
Disease Models, Animal
Fatty Acid Desaturases / genetics
Fatty Acids / metabolism*
Gene Expression
Hemeproteins / metabolism
Liver / metabolism*
Metabolic Syndrome X / metabolism*
RNA, Messenger / metabolism
Rats, Inbred SHR
Rats, Inbred WKY
Reg. No./Substance:
0/Carrier Proteins; 0/Fatty Acids; 0/Hemeproteins; 0/RNA, Messenger; 0/heme-binding protein; EC 1.14.19.-/Fatty Acid Desaturases; EC 2.3.1.-/Acetyltransferases; EC 2.3.1.-/fatty acid elongases
Erratum In:
Biol Pharm Bull. 2012;35(6):997

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