Document Detail

Characterization and factors associated with sleep quality in adolescents with bipolar I disorder.
MedLine Citation:
PMID:  21701911     Owner:  NLM     Status:  MEDLINE    
Sleep disturbance is an early marker for bipolar disorder (BD) onset in youth. We characterized sleep quality in adolescents experiencing mania within the last 6-12 months. We examined the association between mood and sleep in 27 adolescents with BD and 24 matched healthy controls (HC). Subjects were assessed by parent and teen report of sleep, a semi-structured clinical interview, the Young Mania Rating Scale (YMRS), and the Childhood Depression Rating Scale (CDRS-R). Average BD youth YMRS (mean 20.3 ± 7.3) and CDRS-R (mean 42.4 ± 14.1) scores indicated they were still ill at time of assessment. Compared to HCs, adolescents with BD have distinct patterns of prolonged sleep onset latency, frequent nighttime awakenings, and increased total time awake. Mood symptoms, specifically excessive guilt, self-injurious behavior, and worsening evening mood, interfered with sleep. Further studies are needed to determine whether early regulation of sleep would improve long-term outcome in BD youth.
Donna J Roybal; Kiki D Chang; Michael C Chen; Meghan E Howe; Ian H Gotlib; Manpreet K Singh
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Child psychiatry and human development     Volume:  42     ISSN:  1573-3327     ISO Abbreviation:  Child Psychiatry Hum Dev     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-10     Completed Date:  2012-03-15     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  1275332     Medline TA:  Child Psychiatry Hum Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  724-40     Citation Subset:  IM    
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MeSH Terms
Affect / drug effects*
Bipolar Disorder* / complications,  diagnosis,  drug therapy,  psychology
Interview, Psychological
Psychiatric Status Rating Scales
Psychotropic Drugs / therapeutic use
Risk Factors
Self Report
Self-Injurious Behavior* / etiology,  prevention & control,  psychology
Sleep / drug effects*
Sleep Disorders* / diagnosis,  drug therapy,  etiology,  psychology
Grant Support
Reg. No./Substance:
0/Psychotropic Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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