Document Detail


Characterization of changes to the mechanical properties of arteries due to cold storage using nanoindentation tests.
MedLine Citation:
PMID:  22230967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Understanding the effect of cold storage on arterial tissues is essential in various clinical and experimental practices. Cold storage techniques could significantly affect the post-cryosurgical or post-cryopreservation mechanical behavior of arteries. Previously, arteries were considered homogenous and elastic and the changes in material properties due to cold storage were inconclusive. In this study, using a custom-made nanoindentation device, changes to the local viscoelastic properties of porcine thoracic aorta wall due to three common storage temperatures (+4, -20, and -80 °C) within 24 h, 48 h, 1 week, and 3 weeks were characterized. The changes to both elastic and relaxation behaviors were investigated considering the multilayer, heterogeneous nature of the aortic wall. The results showed that the average instantaneous Young's modulus (E) of +4 °C storage samples decreased while their permanent average relaxation amplitude (G (∞)) increased and after 48 h these changes became significant (10 and 13% for E and G (∞), respectively). Generally, in freezer storage, E increased and G (∞) showed no significant change. In prolonged preservation (>1 week), the results of -20 °C showed significant increase in E (20% after 3 weeks) while this increase for -80 °C was not significant, making it a better choice for tissue cold storage applications.
Authors:
Ali Hemmasizadeh; Kurosh Darvish; Michael Autieri
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-01-10
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  40     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-18     Completed Date:  2012-10-31     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1434-42     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries*
Cryopreservation*
Elasticity*
Freezing*
Swine
Time Factors
Grant Support
ID/Acronym/Agency:
K25 HL086512/HL/NHLBI NIH HHS; K25 HL086512-03/HL/NHLBI NIH HHS; K25HL086512-03/HL/NHLBI NIH HHS; R21HL088159-02/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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