| Characterization of cardiac time intervals in healthy bonnet macaques (Macaca radiata) by using an electronic stethoscope. | |
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MedLine Citation:
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PMID: 21439218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nonhuman primates are used frequently in cardiovascular research. Cardiac time intervals derived by phonocardiography have long been used to assess left ventricular function. Electronic stethoscopes are simple low-cost systems that display heart sound signals. We assessed the use of an electronic stethoscope to measure cardiac time intervals in 48 healthy bonnet macaques (age, 8±5 y) based on recorded heart sounds. Technically adequate recordings were obtained from all animals and required 1.5±1.3 min. The following cardiac time intervals were determined by simultaneously recording acoustic and single-lead electrocardiographic data: electromechanical activation time (QS1), electromechanical systole (QS2), the time interval between the first and second heart sounds (S1S2), and the time interval between the second and first sounds (S2S1). QS2 was correlated with heart rate, mean arterial pressure, diastolic blood pressure, and left ventricular ejection time determined by using echocardiography. S1S2 correlated with heart rate, mean arterial pressure, diastolic blood pressure, left ventricular ejection time, and age. S2S1 correlated with heart rate, mean arterial pressure, diastolic blood pressure, systolic blood pressure, and left ventricular ejection time. QS1 did not correlate with any anthropometric or echocardiographic parameter. The relation S1S2/S2S1 correlated with systolic blood pressure. On multivariate analyses, heart rate was the only independent predictor of QS2, S1S2, and S2S1. In conclusion, determination of cardiac time intervals is feasible and reproducible by using an electrical stethoscope in nonhuman primates. Heart rate is a major determinant of QS2, S1S2, and S2S1 but not QS1; regression equations for reference values for cardiac time intervals in bonnet macaques are provided. |
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Authors:
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Haroon Kamran; Louis Salciccioli; Sergei Pushilin; Paraag Kumar; John Carter; John Kuo; Carol Novotney; Jason M Lazar |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Journal of the American Association for Laboratory Animal Science : JAALAS Volume: 50 ISSN: 1559-6109 ISO Abbreviation: J. Am. Assoc. Lab. Anim. Sci. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-28 Completed Date: 2011-08-03 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 101269489 Medline TA: J Am Assoc Lab Anim Sci Country: United States |
Other Details:
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Languages: eng Pagination: 238-43 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Dissociative Animals Echocardiography Female Heart Rate Heart Sounds Ketamine Laboratory Animal Science / instrumentation, methods*, standards Macaca radiata / physiology* Male Models, Animal Phonocardiography / instrumentation, methods*, standards, veterinary* Reference Values Stethoscopes / veterinary* Ventricular Function, Left* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Dissociative; 6740-88-1/Ketamine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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