Document Detail

Characterization of the C-Terminal Diglycine Motif of SUMO-1/3.
MedLine Citation:
PMID:  22738983     Owner:  NLM     Status:  In-Data-Review    
A hallmark of small ubiquitin-related modifier (SUMO) is the production of a C-terminal tail containing diglycines (GGs), which are believed to be required for SUMOylation. Whether GGs are required components in SUMOylation remains unanswered experimentally. In this study we found that the SUMO-1/3-AA/-GS/-GN/-GA mutant can form sodium dodecyl sulfate (SDS)-dithiothreitol (DTT)-resistant complexes with cellular proteins, indicating that the GG motif is not strictly required for SUMOylation.
Koji Yamada; Miyuki Muramatsu; Daiki Saito; Mai Sato-Oka; Masayuki Saito; Taishi Moriyama; Hisato Saitoh
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Publication Detail:
Type:  Journal Article     Date:  2012-05-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  76     ISSN:  1347-6947     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1035-7     Citation Subset:  IM    
Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University.
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