| Characterization of blood glucose level regulation in mouse opioid withdrawal models. | |
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MedLine Citation:
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PMID: 20226840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The regulation of blood glucose level in intracerebroventricular (i.c.v.) administration with opioid alone or opioid withdrawal model was studied in ICR mice. In the first group, we found that i.c.v. administered morphine or beta-endorphin alone causes an elevation of blood glucose level. Blood glucose level induced by i.c.v. morphine or beta-endorphin began to increase within 30min and reached maximal level at 1h, decreasing to the basal level after 2h. In another group, we observed that intraperitoneal (i.p.) injection with naloxone (10mg/kg) post-treated 3h after either a single i.c.v. injection with morphine or beta-endorphin did not affect the increased blood glucose level in either group. In the next study, we observed that multiple (1 time/day for 3 days) i.c.v. injection with morphine alone significantly increased the blood glucose level. However, i.p. injection with naloxone post-treated 3h after the last i.c.v. injection with morphine caused a decrease of blood glucose level. We found that multiple (1 time/day for 3 days) i.c.v. injections with beta-endorphin did not affect the blood glucose level. Furthermore, i.p. injection with naloxone did not affect the blood glucose level in the mice injected with multiply beta-endorphin. Our results suggest that both morphine and beta-endorphin administered i.c.v. acutely increases the blood glucose level. However, blood glucose levels in the groups of multiply administered morphine alone, beta-endorphin alone, and naloxone-treated withdrawal model in multiply injected morphine and beta-endorphin appear to be differentially regulated. |
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Authors:
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Soo-Hyun Park; Yun-Beom Sim; Yu-Jung Kang; Seon-Mi Kim; Jin-Koo Lee; Jun-Sub Jung; Hong-Won Suh |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-11 |
Journal Detail:
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Title: Neuroscience letters Volume: 476 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-20 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 119-22 Citation Subset: IM |
Copyright Information:
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Copyright 2010. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University, 39 Hallymdaehak-gil, Chuncheon, Gangwon-do, 200-702, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism* Male Mice Mice, Inbred ICR Morphine / adverse effects Naloxone / pharmacology Narcotic Antagonists / pharmacology Opioid-Related Disorders / metabolism* Substance Withdrawal Syndrome / metabolism* beta-Endorphin / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Narcotic Antagonists; 465-65-6/Naloxone; 57-27-2/Morphine; 60617-12-1/beta-Endorphin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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