Document Detail


Characteristics of upper oesophageal sphincter and oesophageal body during maturation in healthy human neonates compared with adults.
MedLine Citation:
PMID:  16185304     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated the upper oesophageal sphincter (UOS) relationship with oesophageal body during primary peristalsis (PP) sequences in healthy human neonates during maturation and compared with that of healthy adult volunteers. Forty-nine studies were performed using a water perfusion manometry system and a specially designed oesophageal catheter with a UOS sleeve concurrent with submental electromyogram in 31 subjects in supine position (18 preterm neonates, 29.9 +/- 2.5 weeks gestation; four full-term neonates, 39.3 +/- 1.0 weeks gestation; and nine adults, 18-65 years). The preterm neonates were studied longitudinally at 33 and 36 weeks postmenstrual age (PMA) and full-term born at 40 weeks PMA. Data were compared between the groups to recognize the effects of gestation, postnatal age and ageing. We evaluated 403 consecutive spontaneous solitary swallows during maturation (preterm at time-1 vs time-2) and growth (preterm and full-term vs adults) and observed significant (P < 0.05) differences in the basal UOS resting pressure, UOS relaxation characteristics, proximal and distal oesophageal body amplitude, duration, propagation and peristaltic velocity. Characteristics of UOS and PP are well-developed by 33 weeks PMA and undergo further maturation during the postnatal period, and are significantly different from that of adult.
Authors:
S R Jadcherla; H Q Duong; C Hofmann; R Hoffmann; R Shaker
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  17     ISSN:  1350-1925     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-27     Completed Date:  2005-11-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  663-70     Citation Subset:  IM    
Affiliation:
Sections of Neonatology, Pediatric Gastroenterology and Nutrition, Columbus Children's Hospital, Department of Pediatrics, The Ohio State University School of Medicine and Public Health, 43205, USA. jadcherlas@pediatrics.ohio-state.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aging
Birth Weight
Deglutition
Esophagus / anatomy & histology,  growth & development*,  physiology*
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Male
Manometry
Reference Values
Supine Position
Grant Support
ID/Acronym/Agency:
1 R03 61502//PHS HHS; M01-RR00058/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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