Document Detail

Characteristics of the transport of ascorbic acid into leucocytes.
MedLine Citation:
PMID:  3807646     Owner:  NLM     Status:  MEDLINE    
The degree and the mode of association of [14C]-ascorbic acid with leucocytes are examined. The degree of association of ascorbic acid with polymorphonuclear leucocytes (1-3%) is dependent on cell type, extracellular concentration of ascorbic acid, incubation temperature, intactness of the cells and the extracellular pH. All experiments are performed according to strict protocols as these compounds are labile in aqueous solutions. Further it is noticed that in all experiments an outward gradient of leucocyte endogenic ascorbic acid exists. The results suggest that the association process comprises at least one saturable pathway. The activation of polymorphonuclear leucocytes by phorbol myristate acetate increases the accumulation of ascorbic acid threefold.
M Raghoebar; J A Huisman; W B van den Berg; C A van Ginneken
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  40     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-03-02     Completed Date:  1987-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  499-510     Citation Subset:  IM    
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MeSH Terms
Ascorbic Acid / metabolism*
Biological Transport
Dehydroascorbic Acid / metabolism
Glucose / pharmacology
Hydrogen-Ion Concentration
Inflammation / metabolism
Neutrophils / metabolism*
Probenecid / pharmacology
Reg. No./Substance:
490-83-5/Dehydroascorbic Acid; 50-81-7/Ascorbic Acid; 50-99-7/Glucose; 57-66-9/Probenecid

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