Document Detail

Characteristics of systolic time intervals in patients with pheochromocytoma.
MedLine Citation:
PMID:  2061991     Owner:  NLM     Status:  MEDLINE    
The effect of chronic catecholamine excess on cardiac function was assessed in 8 patients with surgically proven pheochromocytoma and the results compared with data obtained from normal controls and essential hypertensives. Major findings in systolic time intervals (STI) in patients with pheochromocytoma were a marked shortening of electromechanical systole and left ventricular ejection time (ET), but pre-ejection period (PEP) remained within normal limits. These findings were not altered by correction for heart rate. The ET/PEP ratio was very low (1.87 +/- 0.31) due to the remarkable shortening of ET. The ET/PEP ratio in essential hypertensives was also low (1.77 +/- 0.38), but this was mainly due to a remarkable prolongation of PEP. Low cardiac index, low stroke index and high total peripheral resistance index were preoperative characteristics in patients with pheochromocytoma, but returned to normal after operation. These results suggest that chronic excessive production of catecholamines from pheochromocytoma has deleterious effects on the heart, and that wide differences in STI exist between patients with pheochromocytoma and those with essential hypertension.
M Hamada; T Ito; K Hiwada; T Kokubu; A Genda; R Takeda
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  55     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-08-06     Completed Date:  1991-08-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  417-26     Citation Subset:  IM    
2nd Department of Internal Medicine, Ehime University School of Medicine, Japan.
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MeSH Terms
Adrenal Gland Neoplasms / physiopathology*,  surgery
Catecholamines / physiology
Hypertension / physiopathology
Middle Aged
Pheochromocytoma / physiopathology*,  surgery
Postoperative Period
Stroke Volume
Systole / physiology*
Ventricular Function, Left
Reg. No./Substance:

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