Document Detail

Characteristics of sleep-disordered breathing in Japanese patients with acromegaly.
MedLine Citation:
PMID:  21996595     Owner:  NLM     Status:  Publisher    
Sleep-disordered breathing (SDB), especially sleep apnea-hypopnea syndrome (SAS), is often observed in patients with active acromegaly. This complication is a risk factor for cardiovascular disease and associated with increased morbidity and mortality in acromegaly. However there is little information on SDB in Japanese patients with acromegaly. We investigated the prevalence of SDB and association between the severity of SDB and various features and biomarkers in Japanese patients with acromegaly. Twenty-four Japanese patients with active acromegaly underwent overnight cardiorespiratory monitoring, hormonal assays and cephalometric measurements on X-ray. A high prevalence of SDB was detected in acromegaly (87.5%). Log apnea-hypopnea index (AHI) correlated positively with soft palate length / body height (X-ray) (r=0.44, p=0.043), but not with log growth hormone levels and insulin-like growth factor type-1 standard deviation scores, size of pituitary adenoma, disease duration, body mass index, waist circumference, estimated visceral fat area, heel pad thickness / height, tongue thickness/ height, or oropharyngeal dimension/ height. In conclusion, our study demonstrated a high prevalence of SDB in Japanese patients with acromegaly, and its severity correlated with soft palate length. Based on the high incidence of SDB identified in the present study, we recommend that all patients with acromegaly are routinely screened for SDB for early diagnosis and treatment.
Susumu Kashine; Ken Kishida; Tohru Funahashi; Iichiro Shimomura
Related Documents :
20802415 - The sequence polymorphism of mnsod gene in subjects with respiratory insufficiency in c...
11896895 - Pulmonary hypertension in patients with chronic obstructive pulmonary disease: recent a...
15168215 - Cpap-therapy effectively lowers serum homocysteine in obstructive sleep apnea syndrome.
2975285 - Ipratropium bromide: bronchodilator action and effect on methacholine-induced bronchoco...
24894375 - Esophageal peristaltic defects in adults with functional dysphagia.
16502215 - Multiple sclerosis and autoimmune diseases: epidemiology and hla-dr association in nort...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-12
Journal Detail:
Title:  Endocrine journal     Volume:  -     ISSN:  1348-4540     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departments of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Plasma plasminogen activator inhibitor-1 levels in the different phenotypes of the polycystic ovary ...
Next Document:  Insignificance of prophylactic upper mediastinal lymph node dissection by sternotomy for papillary t...